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Cat. No.: HY-161045

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T-1-DOCA

T-1-DOCA ia a EGFR inhibitor, with the IC₅₀ of 56.94 and 269.01?nM for EGFR^WT and EGFR^T790M, respectively. T-1-DOCA can induces cell apoptosis of HCT-116 cells.

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Formule: C₁₅H₁₃Cl₂N₅O₃
Masse moléculaire:382.20

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

T-1-DOCA Chemical Structure

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique

Description

T-1-DOCA ia a EGFR inhibitor, with the IC₅₀ of 56.94 and 269.01?nM for EGFR^WT and EGFR^T790M, respectively. T-1-DOCA can induces cell apoptosis of HCT-116 cells^[1].

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Chemical Information

Masse moléculaire 382.20
Formule C₁₅H₁₃Cl₂N₅O₃
SMILES

O=C(C(N(C)C=N1)=C1N2C)N(CC(NC3=C(Cl)C=CC=C3Cl)=O)C2=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Eissa IH, et al. Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer. Evol Bioinform Online. 2023;19:11769343231217916. Published 2023 Dec 1. [Content Brief]

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Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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T-1-DOCA

Voir tous les produits spécifiques à Isoform EGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

T-1-DOCA Related Classifications

HY-161045 Related Classifications