TPP-1 TFA
TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function.
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- Formule: C109H151F3N34O34S2
- Masse moléculaire:2602.70
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
TPP-1 TFA binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 TFA peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 TFA to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].TPP-1 TFA (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 TFA group shows similar outcomes for cell proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:5- to 6-week-old female Balb/c nude mice injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector[1]
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Dosage:4 mg/kg
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Administration:Subcutaneous injection; 4 mg/kg; every other day eight times; 32 days
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Result:Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.
Chemical Information
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Masse moléculaire 2602.70
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Formule C109H151F3N34O34S2
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Sequence
Ser-Gly-Gln-Tyr-Ala-Ser-Tyr-His-Cys-Trp-Cys-Trp-Arg-Asp-Pro-Gly-Arg-Ser-Gly-Gly-Ser-Lys
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Sequence Shortening
SGQYASYHCWCWRDPGRSGGSK
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TPP-1 TFA Related Classifications
HY-P3139A Related Classifications
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