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Cat. No.: HY-12328

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Trk-IN-2

Trk-IN-2 is an orally active pan-Trk kinase inhibitor with an TrkA IC₅₀ of 9 nM. Trk-IN-2 exhibits pharmacodynamic effects in rat models of inflammatory pain and neuropathic pain.Trk-IN-2 can be used for the research of inflammatory pain, neuropathic pain.

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CAS No.: 1614229-04-7
Formule: C₂₄H₂₄N₁₀O
Masse moléculaire:468.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Trk-IN-2 Chemical Structure

CAS No.: 1614229-04-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Trk Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	7 nM Compound: 11	Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay Inhibition of human TrkA expressed in human U2OS cells assessed as inhibition of NGF-induced maximum response after 1 hr by beta-galactosidase assay	[PMID: 24914455]

In Vitro

Trk-IN-2 (compound 11) inhibits TrkA with an IC₅₀ of 7 nM in cell-based assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1614229-04-7
Masse moléculaire 468.53
Formule C₂₄H₂₄N₁₀O
SMILES

O=C(NC1=CC(=NN1C=2C=NC=CC2)C(C)(C)C)CN3N=NC(=C3)C=4C=NC(=CC4)N5C=NC=C5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Norman BH, et al. Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem. 2017;60(1):66-88. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Trk-IN-2

Voir tous les produits spécifiques à Isoform Trk Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Trk-IN-2 Related Classifications

HY-12328 Related Classifications