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Cat. No.: HY-183886

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U 80493

U 80493 is a HIV-1 reverse transcriptase inhibitor with IC₅₀ of 20 μM. U 80493 can be used for the research of acquired immunodeficiency syndrome.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 136816-67-6
Formule: C₂₁H₃₀N₄O
Masse moléculaire:354.49

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Please store the product under the recommended conditions in the Certificate of Analysis.

U 80493 Chemical Structure

CAS No.: 136816-67-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

U 80493 is a HIV-1 reverse transcriptase inhibitor with IC₅₀ of 20 μM. U 80493 can be used for the research of acquired immunodeficiency syndrome^[1].

IC₅₀ & Target^[1]

HIV-1

20 μM (IC₅₀)

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In Vitro

U 80493 (Compound 8) inhibits HIV-1 IIIb replication in MT-2 cells with an ED₅₀ of 2 μM and has a CC₅₀ of 15 μM^[1].
U 80493 inhibits HIV-1 D34 replication in PBMC with an ED₅₀ of 1-10 μM and has a CC₅₀ greater than 10 μM^[1].
U 80493 inhibits HIV-1 IIIb replication in H9 cells with an ED₅₀ of 1 μM and has a CC₅₀ of 10 μM^[1].
U 80493 inhibits recombinant HIV-1 RT activity with an IC₅₀ of 20 μM^[1].
U 80493 (100 μM) inhibits recombinant HIV-1 RT activity by 73%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 136816-67-6
Masse moléculaire 354.49
Formule C₂₁H₃₀N₄O
SMILES

CCNC1=CC=CN=C1N2CCN(CC2)CC3=CC(C)=C(OC)C(C)=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Xu H, et al. Progress of bis(heteroaryl)piperazines (BHAPs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) against human immunodeficiency virus type 1 (HIV-1). Mini Rev Med Chem. 2010;10(1):62-72. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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U 80493

Voir tous les produits spécifiques à Isoform HIV

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

U 80493 Related Classifications

HY-183886 Related Classifications