ZG36
ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model.
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- CAS No.: 2999673-34-4
- Formule: C31H35BrN4O4
- Masse moléculaire:607.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
3.3 μM
Compound: ZG36
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Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 37352796] |
| MOLM-13 | IC50 |
2.9 μM
Compound: ZG36
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Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 37352796] |
| MV4-11 | IC50 |
5.8 μM
Compound: ZG36
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 37352796] |
| NB-4 | IC50 |
4.9 μM
Compound: ZG36
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Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 37352796] |
Chemical Information
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CAS No. 2999673-34-4
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Masse moléculaire 607.54
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Formule C31H35BrN4O4
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SMILES
BrC1=CC=C(CNC(N(CC2)[C@]3([H])N([C@H](C(N(C3)CC4=C5C(C=CC=C5)=C(OC)C=C4)=O)[C@H](CC)C)C2=O)=O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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