113-53-1
Chemical Structure
Dothiepin
Synonym(s): Dosulepin; Dothep
- CAS No.: 113-53-1
- Formula:C19H21NS
- Molecular Weight:295.44
IUPAC Name: (E)-3-(dibenzo[b,e]thiepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine
InChIKey: PHTUQLWOUWZIMZ-GZTJUZNOSA-N
SMILES: CN(C)CC/C=C1C2=CC=CC=C2SCC3=CC=CC=C/13
Biological Activity: Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].
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Dothiepin | 98.50% | Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain，idiopathic fibromyalgia syndrome or rheumatoid arthritis. | ||||||||||||||||||||
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Dothiepin-d3 | Dothiepin-d3 is the deuterium labeled Dothiepin. | |||||||||||||||||||||
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Dothiepin-d6 hydrochloride | Dothiepin-d6 (hydrochloride) is the deuterium labeled Dothiepin hydrochloride. | |||||||||||||||||||||
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