129-16-8
Chemical Structure
Merbromin
Synonym(s): Mercury dibromofluorescein disodium salt; ZP1
- CAS No.: 129-16-8
- Formula:C20H10Br2HgNa2O6
- Molecular Weight:752.67
IUPAC Name: sodium (2,7-dibromo-9-(2-carboxylatophenyl)-6-hydroxy-3-oxido-9H-xanthen-4-yl)(hydroxy)mercury
InChIKey: VHCGNQTXCDECHY-UHFFFAOYSA-K
SMILES: O[Hg]C1=C(O[Na])C(Br)=CC(C2C3=C(C=CC=C3)C(O[Na])=O)=C1OC4=C2C=C(Br)C(O)=C4
Biological Activity: Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC50 of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye[1][2].
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Merbromin | Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC50 of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye. | |||||||||||||||||||||
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References
- [1]. Xiangling Cui , et al. Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313. [Content Brief]
- [2]. Junjie Chen, et al. Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2. Biochem Biophys Res Commun. 2022 Feb 5:591:118-123. [Content Brief]
