13655-52-2
13655-52-2
Chemical Structure
Alprenolol
Synonym(s): (RS)-Alprenolol; dl-Alprenolol
- CAS No.: 13655-52-2
- Formula:C15H23NO2
- Molecular Weight:249.35
IUPAC Name: 1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol
InChIKey: PAZJSJFMUHDSTF-UHFFFAOYSA-N
SMILES: OC(COC1=CC=CC=C1CC=C)CNC(C)C
Biological Activity: Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alprenolol | 99.94% | Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. | ||||||||||||||||||||
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(E)-Alprenoxime | (E)-Alprenoxime is the isomer of the Alprenoxime. Alprenoxime is a site-activated ocular β-blocker. | |||||||||||||||||||||
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(-)-Dihydroalprenolol | 99.63% | (-)-Dihydroalprenolol (L-Dihydroalprenolol) is a β-adrenergic antagonist that inhibits the activity of β-adrenergic receptors. (-)-Dihydroalprenolol can cause desensitization of approximately 60% of β-adrenergic receptor binding sites. (-)-Dihydroalprenolol has also been shown to reduce the binding capacity of specific β-adrenergic ligands. (-)-Dihydroalprenolol may affect the ability to stimulate membrane-bound adenylate acylase. | ||||||||||||||||||||
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(S)-Alprenolol | (S)-Alprenolol is a potent and nonselective β-blocker. | |||||||||||||||||||||
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(S)-Alprenolol hydrochloride | (S)-Alprenolol hydrochloride is a potent and nonselective β-blocker. | |||||||||||||||||||||
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(+)-Alprenolol | (+)-Alprenolol ((R)-Alprenolol; D-Alprenolol) is a 5-HT1A receptor antagonist with a Ki value of 5400 nM. (+)-Alprenolol also acts as a non-selective β-receptor (β-receptor) blocker. (+)-Alprenolol can be used in the research of cardiovascular and cerebrovascular diseases. | |||||||||||||||||||||
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4-Hydroxyalprenolol | 4-Hydroxyalprenolol (Alp2b) is a metabolite of β-receptor blocker Alprenolol (HY-B1517). | |||||||||||||||||||||
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Oxprenolol hydrochloride | 99.86% | Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle. | ||||||||||||||||||||
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Oxprenolol | Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle. | |||||||||||||||||||||
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Alprenolol hydrochloride | 99.63% | Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. | ||||||||||||||||||||
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Metoprolol impurity 1 (Standard) | ≥98% | 1-(Isopropylamino)-3-(2-(2-methoxyethyl)phenoxy)propan-2-ol (Standard) is the analytical standard of 1-(Isopropylamino)-3-(2-(2-methoxyethyl)phenoxy)propan-2-ol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Himori N, et al. Effects of beta-adrenoceptor blocking agents, pindolol, alprenolol and practolol on blood pressure and heart rate in conscious renal hypertensive dogs. Arch Int Pharmacodyn Ther. 1977 Jan;225(1):152-65. [Content Brief]
- [2]. Fernández-Guasti A, et al. Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone. Psychopharmacology (Berl). 1990;101(3):354-8. [Content Brief]
- [3]. Parratt JR, et al. Myocardial and haemodynamic effects of the beta-adrenoceptor blocking drug alprenolol (H56/28) in anaesthetized cats. Br J Pharmacol. 1969 Oct;37(2):357-66. [Content Brief]
