1453-82-3
1453-82-3
Chemical Structure
Isonicotinamide
- CAS No.: 1453-82-3
- Formula:C6H6N2O
- Molecular Weight:122.12
IUPAC Name: isonicotinamide
InChIKey: VFQXVTODMYMSMJ-UHFFFAOYSA-N
SMILES: NC(C1=CC=NC=C1)=O
Biological Activity: Isonicotinamide is a structural isomer of Nicotinamide (HY-B0150). Isonicotinamide promotes the activity of the NAD+-dependent deacetylase Sir2 in yeast and affects NAD+ homeostasis and nucleotide salvage synthesis pathways. Isonicotinamide can also serve as an intermediate for the synthesis of active drugs[1][2].
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Isonicotinamide | 98.0% | Isonicotinamide is a structural isomer of Nicotinamide (HY-B0150). Isonicotinamide promotes the activity of the NAD+-dependent deacetylase Sir2 in yeast and affects NAD+ homeostasis and nucleotide salvage synthesis pathways. Isonicotinamide can also serve as an intermediate for the synthesis of active drugs. | ||||||||||||||||||||
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Isonicotinamide (Standard) | 99.75% | Isonicotinamide (Standard) is the analytical standard of Isonicotinamide (HY-W012843). This product is intended for research and analytical applications. Isonicotinamide is a structural isomer of Nicotinamide (HY-B0150). Isonicotinamide promotes the activity of the NAD+-dependent deacetylase Sir2 in yeast and affects NAD+ homeostasis and nucleotide salvage synthesis pathways. Isonicotinamide can also serve as an intermediate for the synthesis of active drugs. | ||||||||||||||||||||
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Isonicotinamide-d4 | 99.91% | Isonicotinamide-d4 is the deuterated-labeled Isonicotinamide (HY-W012843). Isonicotinamide is a structural isomer of Nicotinamide (HY-B0150). Isonicotinamide promotes the activity of the NAD+-dependent deacetylase Sir2 in yeast and affects NAD+ homeostasis and nucleotide salvage synthesis pathways. Isonicotinamide can also serve as an intermediate for the synthesis of active drugs. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-B0150Nicotinamide -
Similarity Score 0.90
HY-B0150S1Nicotinamide-15N,13C3 -
Similarity Score 0.90
HY-B0150S2Nicotinamide-13C6 -
Similarity Score 0.90
HY-W744757Nicotinamide-15N -
Similarity Score 0.88
HY-B0150ANicotinamide hydrochloride -
Similarity Score 0.86
HY-B0329Isoniazid -
Similarity Score 0.86
HY-N7130Thioisonicotinamide -
Similarity Score 0.86
HY-I0736RIsonicotinic acid (Standard) -
Similarity Score 0.85
HY-Y01794-Acetylpyridine -
Explore the MedChemAI to find more analogs
References
- [1]. Kalita AI, et al. Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation. The Journal of biological chemistry. 2026 Mar;302(3):111158.
- [2]. Oettgen HF, et al. Potentiation of the Anti-leukemic Effects of 2-Aminothiadiazole by Isonicotinamide and Derivatives. Cancer Research. 1964 May 1;24(4_Part_1):689-92.
