147366-41-4
147366-41-4
Chemical Structure
MKT-077
Synonym(s): FJ-776
- CAS No.: 147366-41-4
- Formula:C21H22ClN3OS2
- Molecular Weight:432.00
IUPAC Name: 1-ethyl-2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)pyridin-1-ium chloride
InChIKey: VSKYOTRJSLYFHX-UXJRWBAGSA-M
SMILES: CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-]
Biological Activity: MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity[1]. MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MKT-077 | 98.49% | MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity. MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm. | ||||||||||||||||||||
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JG-48 | JG-48 is a Hsp70 inhibitor that can reduce tau levels in models of tauopathy. | |||||||||||||||||||||
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JG-98 | 99.88% | JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages. | ||||||||||||||||||||
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FJ-5002 | FJ-5002 is a telomerase inhibitor with an IC50 of 2 μM. FJ-5002 can induce telomere shortening, increased chromosomal abnormalities, and senescence/crisis-like features in the human leukemia cell line U937. FJ-5002 exhibits antitumor activity and can be used in the study of cancer. | |||||||||||||||||||||
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JG-231 | 98.47% | JG-231 is an allosteric inhibitor of heat shock protein 70 (Hsp70). JG - 231 inhibits the binding of Hsp70 and BAG family proteins, including inhibition of Hsp70 and BAG1 with a Ki of 0.11 μM. JG-231 inhibits proliferation of tumor cells and induces apoptosis. JG-231 has antitumor activity. | ||||||||||||||||||||
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YM-08 | YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70. | |||||||||||||||||||||
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SJL 01 | SJL 01 (Compound 8) is an anti-parasitic agent. SJL 01 (Compound 8) is cytotoxic to L-6 myocytes and exhibits antileishmaniasis activity both in vivo and in vitro. SJL 01 can be used for visceral leishmaniasis research. | |||||||||||||||||||||
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JG-258 | JG-258 is an inactive negative control for Hsp70 inhibitors. JG-258 is an inactive structural analog of JG-98 (HY-117282), an allosteric inhibitor of heat shock protein 70 (Hsp70) with demonstrated anticancer activity. JG-258 can be used in cancer-related research. | |||||||||||||||||||||
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JG-23 | 99.64% | JG-23 is a 4-chloro modified analog with ability to promote t-tau degradation. JG-23 exhibits good metabolic stability with a long T1/2 value (36 min) in mouse liver microsome assays. | ||||||||||||||||||||
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YM-1 | 98.49% | YM-1 is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins. | ||||||||||||||||||||
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YM-1 tosylate | YM-1 tosylate is a stable MKT-077 (HY-15096) analog and an orally active Hsp70 inhibitor. YM-1 tosylate induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins. | |||||||||||||||||||||
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References
- [1]. Starenki D, et al. Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul). 2015 Dec;30(4):593-603. [Content Brief]
- [2]. Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11).. [Content Brief]
