1592908-75-2
1592908-75-2
Chemical Structure
MSN-50
- CAS No.: 1592908-75-2
- Formula:C36H38BrN3O6
- Molecular Weight:688.61
IUPAC Name: N-((S)-1-((((2R,3S)-3-amino-6-((2-methoxyethoxy)methoxy)-2,3-dihydrobenzofuran-2-yl)methyl)(4-bromobenzyl)amino)-1-oxo-3-phenylpropan-2-yl)benzamide
InChIKey: QRQAGDGLLUPMLV-IGOOQNSHSA-N
SMILES: O=C(C1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N(CC3=CC=C(C=C3)Br)C[C@H]4OC5=CC(OCOCCOC)=CC=C5[C@@H]4N)=O
Biological Activity: MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MSN-50 | 98.09% | MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection. | ||||||||||||||||||||
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Bentysrepinine | Bentysrepinine (Y101) is an orally active HBV inhibitor with anti-hepatitis B virus infection activity. Bentysrepinine exhibits favorable pharmacokinetic characteristics, with absolute bioavailability of 44.9%, 43.1%, and 19.2% in rats, dogs, and monkeys, respectively, and it does not accumulate in monkeys after 90 days of oral administration. Bentysrepinine is under research in the antiviral and hepatitis fields. | |||||||||||||||||||||
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Tiropramide | Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia. | |||||||||||||||||||||
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MSN-125 | 99.67% | MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity. | ||||||||||||||||||||
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TIPP | TIPP is a potent and selective δ-opioid antagonist with a Ki value of 1.22 nM. | |||||||||||||||||||||
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CHIR 4531 | CHIR 4531, a trimer peptide, is a opiate ligand that binds to the mu-opiate receptor with a Ki of 6 nM. | |||||||||||||||||||||
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NCL1 | NCL1 is a phenylcyclopropylamine (PCPA)-based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC50 values of 2.5 and 26 μM for LSD1 and LSD2, respectively. | |||||||||||||||||||||
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Dihydro K22 | Dihydro K22 is a derivative of the antiviral agent K22 (HY-122668). | |||||||||||||||||||||
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Tiropramide hydrochloride | Tiropramide (CR 605) hydrochloride is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide hydrochloride relaxes smooth muscle in rabbit isolated colon. Tiropramide hydrochloride can be used for the research of irritable colon and biliary dyskinesia. | |||||||||||||||||||||
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Aurantiamide benzoate | 99.07% | Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC50 value of 70 μM. | ||||||||||||||||||||
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KVD-001 | 99.73% | KVD-001 is a potent plasma kallikrein inhibitor. KVD-001 can be used for diabetic macular edema research. | ||||||||||||||||||||
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References
- [1]. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017;24(4):493-506.e5. [Content Brief]
- [2]. Jensen K, et al. Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax. Exp Biol Med (Maywood). 2019;244(8):621-629. [Content Brief]
