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Cat. No.: HY-120277

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TIPP

(Synonyms: H-Tyr-Tic-Phe-Phe-OH)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

TIPP is a potent and selective δ-opioid antagonist with a K_i value of 1.22 nM.

For research use only. We do not sell to patients.

CAS No.: 146369-65-5
Formula: C₃₇H₃₈N₄O₆
Molecular Weight:634.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

TIPP Chemical Structure

CAS No.: 146369-65-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TIPP is a potent and selective δ-opioid antagonist with a K_i value of 1.22 nM^[1].

All Opioid Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	22700 nM Compound: TIPP	Binding assay evaluated using DAMGO radioligand in CHO cells transfected with rat Opioid receptor mu 1 Binding assay evaluated using DAMGO radioligand in CHO cells transfected with rat Opioid receptor mu 1	[PMID: 11150176]
CHO	IC₅₀	5.8 nM Compound: TIPP	Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1 Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1	[PMID: 11150176]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 146369-65-5
Molecular Weight 634.72
Formula C₃₇H₃₈N₄O₆
SMILES

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@H]3N(C([C@H](CC4=CC=C(O)C=C4)N)=O)CC5=CC=CC=C5C3
Synonyms

H-Tyr-Tic-Phe-Phe-OH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Behav Pharmacol

2026 May 29.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schiller PW, et al. The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers. 1999;51(6):411-25. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- Clinical Trial
Chemical Information
Publications (1)
Purity & Documentation
References

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TIPP

Publications Citing Use of MedChemExpress (MCE) TIPP

All Opioid Receptor Isoforms