203115-63-3

NSC 617145 Chemical Structure
203115-63-3

Chemical Structure

NSC 617145

  • CAS No.: 203115-63-3
  • Formula:C13H10Cl4N2O4
  • Molecular Weight:400.04

IUPAC Name: 1,1'-(2,2-dimethylpropane-1,3-diyl)bis(3,4-dichloro-1H-pyrrole-2,5-dione)

InChIKey: PCOXPBOKDABARQ-UHFFFAOYSA-N

SMILES: O=C(C(Cl)=C(Cl)C1=O)N1CC(C)(C)CN2C(C(Cl)=C(Cl)C2=O)=O

Biological Activity: NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases[1].

Cat. No. Product Name Purity Description Pricing
HY-110185 		NSC 617145 99.53% NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases.
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