203115-63-3
203115-63-3
Chemical Structure
NSC 617145
- CAS No.: 203115-63-3
- Formula:C13H10Cl4N2O4
- Molecular Weight:400.04
IUPAC Name: 1,1'-(2,2-dimethylpropane-1,3-diyl)bis(3,4-dichloro-1H-pyrrole-2,5-dione)
InChIKey: PCOXPBOKDABARQ-UHFFFAOYSA-N
SMILES: O=C(C(Cl)=C(Cl)C1=O)N1CC(C)(C)CN2C(C(Cl)=C(Cl)C2=O)=O
Biological Activity: NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NSC 617145 | 99.53% | NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases. | ||||||||||||||||||||
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NSC 617145 (Standard) | ≥98% | NSC 617145 (Standard) is the analytical standard of NSC 617145 (HY-110185). This product is intended for research and analytical applications. NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.57
HY-W0119571,4-Bis-maleimidobutane -
Similarity Score 0.57
HY-W0170611,6-Bismaleimidohexane -
Similarity Score 0.57
HY-W0135381,2-Bis(maleimido)ethane -
Similarity Score 0.56
HY-124811IRES-C11 -
Similarity Score 0.56
HY-49223diMal-O-CH2COOH -
Similarity Score 0.56
HY-W106411DTME -
Similarity Score 0.56
HY-W190746Mal-PEG1-Mal -
Similarity Score 0.55
HY-W1230311,8-Bismaleimidotriethyleneglycol -
Similarity Score 0.54
HY-76201Dexrazoxane hydrochloride -
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