228577-00-2
228577-00-2
Chemical Structure
TZD18
- CAS No.: 228577-00-2
- Formula:C27H27NO5S
- Molecular Weight:477.57
IUPAC Name: 5-(3-(3-(4-phenoxy-2-propylphenoxy)propoxy)phenyl)thiazolidine-2,4-dione
InChIKey: ZNLPWBJCSSSCCR-UHFFFAOYSA-N
SMILES: O=C(SC1C2=CC=CC(OCCCOC3=CC=C(C=C3CCC)OC4=CC=CC=C4)=C2)NC1=O
Biological Activity: TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC50 values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes[1].
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TZD18 | TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC50 values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes. | |||||||||||||||||||||
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References
Keywords
