2362539-97-5
Chemical Structure
CWHM-1008
- CAS No.: 2362539-97-5
- Formula:C22H26F3N3O
- Molecular Weight:405.46
IUPAC Name: (3R,4S)-N-((S)-1-(4-(dimethylamino)phenyl)ethyl)-4-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide
InChIKey: BNAUPWAOLQXQJZ-KPOBHBOGSA-N
SMILES: C[C@H](NC([C@H]1CNC[C@@H]1C2=CC=C(C(F)(F)F)C=C2)=O)C3=CC=C(N(C)C)C=C3
Biological Activity: CWHM-1008 is an orally active 4-arylpyrrolidine-3-carboxamide compound with both antimalarial and antiproliferative activities. CWHM-1008 inhibits Plasmodium falciparum. CWHM-1008 blocks the Akt/mTOR pathway in lung adenocarcinoma cells, inducing apoptosis and protective autophagy. CWHM-1008 inhibits the growth of Plasmodium falciparum and Plasmodium chabaudi ASCQ parasitemia in mice. CWHM-1008 inhibits the growth of lung adenocarcinoma xenograft tumors in mice. CWHM-1008 can be used for research on lung adenocarcinoma and malaria[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CWHM-1008 | 99.24% | CWHM-1008 is an orally active 4-arylpyrrolidine-3-carboxamide compound with both antimalarial and antiproliferative activities. CWHM-1008 inhibits Plasmodium falciparum. CWHM-1008 blocks the Akt/mTOR pathway in lung adenocarcinoma cells, inducing apoptosis and protective autophagy. CWHM-1008 inhibits the growth of Plasmodium falciparum and Plasmodium chabaudi ASCQ parasitemia in mice. CWHM-1008 inhibits the growth of lung adenocarcinoma xenograft tumors in mice. CWHM-1008 can be used for research on lung adenocarcinoma and malaria. | ||||||||||||||||||||
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References
- [1]. Meyers MJ, et al. 4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides. Journal of medicinal chemistry. 2019 Apr 11;62(7):3503-3512. [Content Brief]
- [2]. Zhang J, et al. CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells. Journal of oncology. 2021;2021:5548128. [Content Brief]
- [3]. Luo R, et al. POU2F2 aggravates cell proliferation and autophagy in lung adenocarcinoma. Journal of Men's Health. 2024;20(7):96-103.
