2417159-57-8
Chemical Structure
C004019
- CAS 番号: 2417159-57-8
- Formula:C49H70N12O9S2
- Molecular Weight:1035.29
IUPAC Name: (2R,4S)-1-((S)-2-(4-(4-acetyl-1,4-diazepan-1-yl)-6-((2-(thiophen-2-yl)ethyl)amino)-1,3,5-triazin-2-yl)-18-(tert-butyl)-4,16-dioxo-8,11,14-trioxa-2,5,17-triazanonadecan-19-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: IXTMPMLKABNFTQ-LLIFGLRNSA-N
SMILES: O=C(N1[C@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCNC(CN(C4=NC(N5CCN(CCC5)C(C)=O)=NC(NCCC6=CC=CS6)=N4)C)=O)=O
Biological Activity: C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimer's disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases[1].
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C004019 | 99.72% | C004019 is a BBB-penetrable and small-molecule PROTAC that targets tau. C004019 can simultaneously recruit tau and E3 ligase, and effectively clear tau proteins by promoting the ubiquitination and proteasome-dependent degradation of tau, thereby improving synaptic and cognitive functions in Alzheimer's disease (AD) mice. C004019 can be used in the research of AD and tau protein-related diseases. | ||||||||||||||||||||
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Keywords
