256928-75-3
Chemical Structure
2-Methylbutyrylcarnitine
Synonym(s): 2MBC
- CAS No.: 256928-75-3
- Formula:C12H23NO4
- Molecular Weight:245.32
IUPAC Name: (3R)-3-((2-methylbutanoyl)oxy)-4-(trimethylammonio)butanoate
InChIKey: IHCPDBBYTYJYIL-QVDQXJPCSA-N
SMILES: CCC(C)C(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O
Biological Activity: 2-Methylbutyrylcarnitine (2MBC) is an orally active short-chain branched-chain acylcarnitine and a gut microbiota co-metabolite produced from 2-methylbutyric acid via branched-chain amino acid catabolism. 2-Methylbutyrylcarnitine activates platelet integrin α2β1 (Kd = 10.6 μM), initiates the downstream p38‑cPLA2 signaling cascade, elevates TXA2 production, and thereby enhances platelet hyperreactivity. 2-Methylbutyrylcarnitine can be used in research on atherosclerosis and thrombosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Methylbutyrylcarnitine | 99.83% | 2-Methylbutyrylcarnitine (2MBC) is an orally active short-chain branched-chain acylcarnitine and a gut microbiota co-metabolite produced from 2-methylbutyric acid via branched-chain amino acid catabolism. 2-Methylbutyrylcarnitine activates platelet integrin α2β1 (Kd = 10.6 μM), initiates the downstream p38‑cPLA2 signaling cascade, elevates TXA2 production, and thereby enhances platelet hyperreactivity. 2-Methylbutyrylcarnitine can be used in research on atherosclerosis and thrombosis. | ||||||||||||||||||||
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References
- [1]. Wen J L, et al. The metabolite 2-Methylbutyrylcarnitine does not Promote Atherosclerosis in Apolipoprotein E-Deficient Mice. BIO Integration (Online), 2024, 5(1).
- [2]. Huang K, et al. Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin α2β1. Cell metabolism. 2024 Mar 05;36(3):598-616.e9. [Content Brief]
