2832159-79-0
Chemical Structure
DS89002333
- CAS No.: 2832159-79-0
- Formula:C22H20ClF2N3O3
- Molecular Weight:447.86
IUPAC Name: N-((S)-(3-chloro-4-fluorophenyl)((2S,4R)-4-hydroxypyrrolidin-2-yl)methyl)-1-fluoro-7-methoxyisoquinoline-6-carboxamide
InChIKey: KALMTELCNYQBGB-MJWYBRSISA-N
SMILES: O=C(N[C@H]([C@]1([H])C[C@@H](O)CN1)C2=CC(Cl)=C(F)C=C2)C3=CC4=CC=NC(F)=C4C=C3OC
Biological Activity: DS89002333 is an orally active and potent PRKACA inhibitor, with an IC50 of 0.3 nM. DS89002333 shows good anti-tumor activity in an FL-HCC patient-derived xenograft model (expressing the DNAJB1-PRKACA fusion gene). DS89002333 can be used in study of fibrolamellar hepatocellular carcinoma (FL-HCC)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DS89002333 | 99.85% | DS89002333 is an orally active and potent PRKACA inhibitor, with an IC50 of 0.3 nM. DS89002333 shows good anti-tumor activity in an FL-HCC patient-derived xenograft model (expressing the DNAJB1-PRKACA fusion gene). DS89002333 can be used in study of fibrolamellar hepatocellular carcinoma (FL-HCC). | ||||||||||||||||||||
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