2919575-27-0
2919575-27-0
Chemical Structure
UCL-TRO-1938
- CAS No.: 2919575-27-0
- Formula:C27H32N6O
- Molecular Weight:456.58
InChIKey: RPOHONUDGBSZDK-UHFFFAOYSA-N
SMILES: O=C(C)N1C2=C(CC1)C=CC=C2NC3=CC(NC4=CC=C(N5CCN(CC5)CC)C=C4)=NC=C3
Biological Activity: UCL-TRO-1938 is a potent small molecule allosteric activator of PI3Kα with an EC50 value of approximately 60 μM. UCL-TRO-1938 can induce cell proliferation and has cardioprotective effects from ischaemia reperfusion injury and enhances nerve regeneration following nerve crush[1][2][3][4][5].
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UCL-TRO-1938 | 99.98% | UCL-TRO-1938 is a potent small molecule allosteric activator of PI3Kα with an EC50 value of approximately 60 μM. UCL-TRO-1938 can induce cell proliferation and has cardioprotective effects from ischaemia reperfusion injury and enhances nerve regeneration following nerve crush. | ||||||||||||||||||||
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References
- [1]. Gong GQ, et al. A small-molecule PI3Kα activator for cardioprotection and neuroregeneration. Nature. 2023 Jun;618(7963):159-168. [Content Brief]
- [2]. Shi H, et al. miR-30c-5p inhibits esophageal squamous cell carcinoma progression by repressing the PI3K/AKT signaling pathway. Thorac Cancer. 2024 Oct;15(30):2206-2216. [Content Brief]
- [3]. Najam O. Exploring the role of cardiac mast cells in acute myocardial infarction and ischaemia-reperfusion injury[D]. UCL (University College London), 2023.
- [4]. Kingwell K. PI3K activator taps route to regeneration. Nat Rev Drug Discov. 2023 Jul;22(7):537. [Content Brief]
- [5]. Ni C, et al. An inappropriate decline in ribosome levels drives a diverse set of neurodevelopmental disorders. bioRxiv [Preprint]. 2024 Jan 9:2024.01.09.574708. [Content Brief]
Keywords
