511-15-9
511-15-9
Chemical Structure
(+)-Totarol
- CAS. Nr.: 511-15-9
- Formula:C20H30O
- Molecular Weight:286.45
IUPAC Name: (4bS,8aS)-1-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-2-ol
InChIKey: ZRVDANDJSTYELM-FXAWDEMLSA-N
SMILES: OC1=CC=C2[C@@]3(C)CCCC(C)(C)[C@]3([H])CCC2=C1C(C)C
Biological Activity: (+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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(+)-Totarol | 98.46% | (+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections. | ||||||||||||||||||||
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14-Hydroxydehydroabietane | 14-Hydroxydehydroabietane is a ribosomal enzyme inhibitor. 14-Hydroxydehydroabietane exhibits in vitro antileishmanial activity against promastigotes, amastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane induces ultrastructural changes in Leishmania braziliensis promastigotes. 14-Hydroxydehydroabietane reduces the infection rate of macrophages by Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane can be used for the research of leishmaniasis. | |||||||||||||||||||||
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Triptonoterpene | 99.12% | Triptonoterpene is a natural product that can be isolated from the roots of Tripterygium wilfordii Hook. f.. | ||||||||||||||||||||
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Dehydroabietal | Dehydroabietal is a natural product found in Pinus brutia var. eldarica, Cedrus atlantica and other organisms. | |||||||||||||||||||||
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Totaradiol | Totaradiol ((+)-Totaradiol; 3β-Hydroxytotarol) is a diterpene can be isolated from Thuja plicata (Cupressaceae). | |||||||||||||||||||||
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Sugiol | 99.88% | Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages. | ||||||||||||||||||||
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Hinokiol | Hinokiol is a natural diterpene. | |||||||||||||||||||||
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Rospiglioside aglycon | Rospiglioside aglycon (4beta-Carboxynortotarol) is a Miscellaneous product that can be isolated from the herbs of Conyza stricta. | |||||||||||||||||||||
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Dehydroabietinol | 98.90% | Dehydroabietinol is a SYK inhibitor with an IC50 of 46.4 μM. Dehydroabietinol inhibits the growth of Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes and Leishmania infantum promastigotes. Dehydroabietinol indirectly inhibits the growth of Plasmodium falciparum, alters the erythrocyte membrane, and induces spherostomatocyte transformation and endovesicle formation. Dehydroabietinol can be used in studies related to immune-mediated diseases, Chagas disease, leishmaniasis and malaria. | ||||||||||||||||||||
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Ferruginol | 96.91% | Ferruginol ((+)-Ferruginol), a natural diterpenoid, is an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). Ferruginol inhibits the growth of thyroid cancer cells through the induction of mitochondrial apoptosis. Ferruginol has antitumor, cardioprotective, antioxidant, gastroprotective, and neuroprotective activities. | ||||||||||||||||||||
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Leelamine | 95.69% | Leelamine is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor with an IC50 value of 9.5 μM, showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells. | ||||||||||||||||||||
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References
- [1]. Bernabeu A, et al. A MAS-NMR study of the location of (+)-totarol, a diterpenoid bioactive molecule, in phospholipid model membranes. Chem Phys Lipids. 2002;119(1-2):33-39. [Content Brief]
- [2]. Micol V, et al. Effects of (+)-totarol, a diterpenoid antibacterial agent, on phospholipid model membranes. Biochim Biophys Acta. 2001 Apr 2;1511(2):281-90. [Content Brief]
