511-15-9
Chemical Structure
(+)-Totarol
- CAS No.: 511-15-9
- Formula:C20H30O
- Molecular Weight:286.45
IUPAC Name: (4bS,8aS)-1-isopropyl-4b,8,8-trimethyl-4b,5,6,7,8,8a,9,10-octahydrophenanthren-2-ol
InChIKey: ZRVDANDJSTYELM-FXAWDEMLSA-N
SMILES: OC1=CC=C2[C@@]3(C)CCCC(C)(C)[C@]3([H])CCC2=C1C(C)C
Biological Activity: (+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections[1][2].
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(+)-Totarol | 98.46% | (+)-Totarol is a diterpenoid membrane-disrupting agent and membrane structure regulator found in plants of the genus Podocarpus spp. (+)-Totarol inserts into phospholipid model membranes, disrupts phospholipid packing, and impairs the functional integrity of membranes. (+)-Totarol exhibits antibacterial activity against a variety of bacterial species and β-lactam-resistant strains, and its action is associated with changes in membrane physical properties. (+)-Totarol can be used in studies related to bacterial infections. | ||||||||||||||||||||
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References
- [1]. Bernabeu A, et al. A MAS-NMR study of the location of (+)-totarol, a diterpenoid bioactive molecule, in phospholipid model membranes. Chem Phys Lipids. 2002;119(1-2):33-39. [Content Brief]
- [2]. Micol V, et al. Effects of (+)-totarol, a diterpenoid antibacterial agent, on phospholipid model membranes. Biochim Biophys Acta. 2001 Apr 2;1511(2):281-90. [Content Brief]
