55965-84-9
Chemical Structure
CMIT/MIT (14.5% in water)
Synonym(s): CMI/MI
- CAS No.: 55965-84-9
- Formula:C8H9ClN2O2S2
- Molecular Weight:264.75
IUPAC Name: 2-methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one (1:1)
InChIKey: QYYMDNHUJFIDDQ-UHFFFAOYSA-N
SMILES: O=C1C=CSN1C.O=C2C=C(SN2C)Cl
Biological Activity: CMIT/MIT is a CMIT and MIT mixture. CMIT and MIT are powerful synthetic biocidal substances. CMIT and MIT are used as preservatives in various cosmetics and industrial products. CMIT and MIT are present in many water-soluble consumer products, such as shampoos, toothpastes. CMIT/MIT (3:1 mixture of CMIT and MIT) produces mitochondrial ROS via inhibiting mitochondrial complex I and II. CMIT/MIT (in 3:1 ratio) induces neurotoxicity through the upregulation of the MAPKs signaling pathways. CMIT/MIT can be used in the research of respiratory diseases and neuroblastoma[1][2][3].
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CMIT/MIT (14.5% in water) | 14.36% | CMIT/MIT is a CMIT and MIT mixture. CMIT and MIT are powerful synthetic biocidal substances. CMIT and MIT are used as preservatives in various cosmetics and industrial products. CMIT and MIT are present in many water-soluble consumer products, such as shampoos, toothpastes. CMIT/MIT (3:1 mixture of CMIT and MIT) produces mitochondrial ROS via inhibiting mitochondrial complex I and II. CMIT/MIT (in 3:1 ratio) induces neurotoxicity through the upregulation of the MAPKs signaling pathways. CMIT/MIT can be used in the research of respiratory diseases and neuroblastoma. | ||||||||||||||||||||
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CMIT/MIT (2.0-2.5% in water) | CMIT/MIT (CMI/MI) 2.0-2.5% in water is a highly effective preservative, wiht also a skin sensitizing effect. Some regions stipulate that the concentration of CMIT/MIT used must not exceed 0.0015%, and it is prohibited from being used in other cosmetics. | |||||||||||||||||||||
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- [1]. Kim D, et al. CMIT/MIT produces mitochondrial ROS via inhibiting mitochondrial complex I and II. Free Radic Biol Med. 2025 Dec 23;244:505-515. [Content Brief]
- [2]. Lee J, et al. CMIT/MIT induce apoptosis and inflammation in alveolar epithelial cells through p38/JNK/ERK1/2 signaling pathway[J]. Molecular & Cellular Toxicology, 2019, 15(1): 41-48.
- [3]. Molinari F, et al. Biocide mixture (CMIT/MIT) induces neurotoxicity through the upregulation of the MAPKs signaling pathways. J Neurophysiol. 2025 Jul 1;134(1):183-192. [Content Brief]
