578-76-7
578-76-7
Chemical Structure
7-Methylguanine
- CAS. Nr.: 578-76-7
- Formula:C6H7N5O
- Molecular Weight:165.15
IUPAC Name: 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one
InChIKey: FZWGECJQACGGTI-UHFFFAOYSA-N
SMILES: O=C1NC(N)=NC2=C1N(C)C=N2
Biological Activity: 7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions[1][2][3][4][5][6].
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7-Methylguanine | 99.97% | 7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions. | ||||||||||||||||||||
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7-Methylguanine (Standard) | ≥98% | Etilefrine (hydrochloride) (Standard) is the analytical standard of Etilefrine (hydrochloride). This product is intended for research and analytical applications. Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension. | ||||||||||||||||||||
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7-Methylguanine-d3 | 7-Methylguanine-d3 is the deuterium labeled 7-Methylguanine. 7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents, and used as a probe of protein–DNA interactions and a key component of DNA sequencing method. | |||||||||||||||||||||
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References
- [1]. Kurgina TA, et al. Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly(ADP-Ribose) Polymerase 1. Biochemistry (Mosc). 2022 Aug;87(8):823-831. [Content Brief]
- [2]. Nilov D, et al. Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine. Int J Mol Sci. 2020 Mar 20;21(6):2159. [Content Brief]
- [3]. Kirsanov K, et al. Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity. Front Pharmacol. 2022 Jul 6;13:842316. [Content Brief]
- [4]. Gaubatz JW, et al. Introduction, distribution, and removal of 7-methylguanine in different liver chromatin fractions of young and old mice. Mutat Res. 1997 Apr 14;375(1):25-35. [Content Brief]
- [5]. Kirsanov K, et al. 7-Methylguanine Inhibits Colon Cancer Growth in Vivo. Acta Naturae. 2024 Apr-Jun;16(2):50-52. [Content Brief]
- [6]. Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130(35):11570-1. [Content Brief]
