5976-61-4
Chemical Structure
4-Hydroxyestradiol
Synonym(s): 4-Hydroxy-17β-estradiol
- CAS No.: 5976-61-4
- Formula:C18H24O3
- Molecular Weight:288.38
IUPAC Name: (8R,9S,13S,14S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,4,17-triol
InChIKey: QOZFCKXEVSGWGS-ZHIYBZGJSA-N
SMILES: C[C@@]12[C@](CC[C@@H]2O)([H])[C@@](CCC3=C4O)([H])[C@@](CC1)([H])C3=CC=C4O
Biological Activity: 4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM[1][2].
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4-Hydroxyestradiol | 99.0% | 4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM. | ||||||||||||||||||||
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4-Hydroxyestradiol (Standard) | ≥98% | ABZ-amine (Standard) is the analytical standard of ABZ-amine. This product is intended for research and analytical applications. ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations. | ||||||||||||||||||||
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4-Hydroxy-17β-estradiol-1,2,16,16,17-d5 | 4-Hydroxy-17β-estradiol-1,2,16,16,17-d5 is the deuterium labeled 4-Hydroxy-17β-estradiol-1,2,16,16,17. | |||||||||||||||||||||
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References
- [1]. Fernandez SV, et al. Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells. Int J Cancer. 2006 Apr 15;118(8):1862-8. doi: 10.1002/ijc.21590. [Content Brief]
- [2]. Van Aswegen CH, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92. [Content Brief]
