6197-30-4
Chemical Structure
Octocrylene
- CAS No.: 6197-30-4
- Formula:C24H27NO2
- Molecular Weight:361.48
IUPAC Name: 2-ethylhexyl 2-cyano-3,3-diphenylacrylate
InChIKey: FMJSMJQBSVNSBF-UHFFFAOYSA-N
SMILES: O=C(OCC(CC)CCCC)/C(C#N)=C(C1=CC=CC=C1)\C2=CC=CC=C2
Biological Activity: Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Octocrylene | 98.68% | Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes. | ||||||||||||||||||||
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Octocrylene (Standard) | 98.08% | Octocrylene (Standard) is the analytical standard of Octocrylene. This product is intended for research and analytical applications. Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. Octocrylene has the potential for using in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation. | ||||||||||||||||||||
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Octocrylene-d10 | 99.78% | Octocrylene-d10 is the deuterium labeled Octocrylene. Octocrylene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. | ||||||||||||||||||||
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Octocrylene-13C3 | Octocrylene-13C3 is the 13C-labeled Octocrylene (HY-A0087). Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes. | |||||||||||||||||||||
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- [1]. E Berardesca, et al. Review of the safety of octocrylene used as an ultraviolet filter in cosmetics. J Eur Acad Dermatol Venereol. 2019 Nov;33 Suppl 7:25-33. [Content Brief]
- [2]. Vatan Ö, et al. Evaluation of cytotoxic and genotoxic potential of avobenzone and octocrylene on human skin fibroblast cells[J]. All Life, 2023, 16(1): 2270171.
- [3]. Meng Q, et al. Toxic effects of octocrylene on zebrafish larvae and liver cell line (ZFL)[J]. Aquatic Toxicology, 2021, 236: 105843. [Content Brief]
- [4]. Ko H, et al. Sunscreen filter octocrylene is a potential obesogen by acting as a PPARγ partial agonist[J]. Toxicology letters, 2022, 355: 141-149. [Content Brief]
- [5]. de Groot A C, et al. Contact and photocontact allergy to octocrylene: a review[J]. Contact dermatitis, 2014, 70(4): 193-204. [Content Brief]
