6879-01-2
Chemical Structure
Tuberostemonine
- CAS No.: 6879-01-2
- Formula:C22H33NO4
- Molecular Weight:375.50
IUPAC Name: (2S,31R,7aR,8R,8aS,11S,11aS,11bR)-8-ethyl-11-methyl-2-((2S,4S)-4-methyl-5-oxotetrahydrofuran-2-yl)dodecahydroazepino[3,2,1-hi]furo[3,2-e]indol-10(2H)-one
InChIKey: GYOGHROCTSEKDY-JJDZUBOLSA-N
SMILES: [H][C@@]([C@]1([H])[C@@]23[H])(CCCCN1[C@]([H])([C@@]4([H])OC([C@@H](C)C4)=O)C3)[C@@H](CC)[C@]([C@]2([H])[C@@H]5C)([H])OC5=O
Biological Activity: Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP+ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent [1][2][3][4].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Tuberostemonine | 99.86% | Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP+ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent . | ||||||||||||||||||||
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Tuberostemonine (Standard) | ≥98% | Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity Ferredoxin-NADP+ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine has a level of activity as a feeding deterrent . | ||||||||||||||||||||
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Sessilifoline A | Sessilifoline A is a Alkaloids product that can be isolated from the roots of Stemona japonica. | |||||||||||||||||||||
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Tuberostemonine D | Tuberostemonine D, an alkaloid obtained, can be obtained from the root of Stemona tuberosa. | |||||||||||||||||||||
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2-Oxostenine | 2-Oxostenine (Compound 7) is a stenine-type alkaloid found in the roots of Stemona tuberosa Lour. 2-Oxostenine can weakly inhibit Lipopolysaccharide (HY-D1056)-induced NO production. 2-Oxostenine can be used for the research of inflammation. | |||||||||||||||||||||
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Tuberostemonine A | Tuberostemonine A is a natural product that can be found in Stemona tuberosa. | |||||||||||||||||||||
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Croomine | Croomine is a tuberostemospironine-type alkaloid. Croomine can be found in Stemona tuberosa, Croomia heterosepala, and Croomia japonica. | |||||||||||||||||||||
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Oxystemoninine | Oxystemoninine is a Stemona alkaloid of the stemonamide type, which can be isolated from the roots of Stemona tuberosa. Oxystemoninine exhibits 1H- and 13C-NMR spectra similar to those of stemoninine (HY-134006). | |||||||||||||||||||||
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Stenine | Stenine (Compound 5) is an alkaloid found in the roots of Stemona sessilifolia. | |||||||||||||||||||||
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Neotuberostemonone | Neotuberostemonone is an alkaloid, that can be isolated from the roots of Stemona mairei (levl.) Krause. | |||||||||||||||||||||
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Neotuberostemonine | 99.93% | Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages. | ||||||||||||||||||||
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Neostenine | Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application. | |||||||||||||||||||||
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References
- [1]. Pudjiastuti P, et al. Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites. J Parasitol Res. 2018 Aug 26;2018:3469132. [Content Brief]
- [2]. Wipf, P., & Spencer, S. R. (2005). Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13-epituberostemonine. Journal of the American Chemical Society, 127(1), 225–235. [Content Brief]
- [3]. Zhou, X., et al., (2009). Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa. Planta medica, 75(6), 575–580. [Content Brief]
- [4]. Jung, K. H., et al., (2016). The therapeutic effects of tuberostemonine against cigarette smoke-induced acute lung inflammation in mice. European journal of pharmacology, 774, 80–86. [Content Brief]
