73326-98-4
Chemical Structure
Drpitor1a
- CAS No.: 73326-98-4
- Formula:C15H8N2O2
- Molecular Weight:248.24
InChIKey: KPOPOVJXCUAKLY-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C=CC=C3)=C3N2)C(C4=CN=CC=C41)=O
Biological Activity: Drpitor1a is an orally active DRP1 GTPase inhibitor. Drpitor1a blocks mitochondrial fission, inhibits DRP1 GTPase activity, and reduces ROS levels. Drpitor1a induces mitochondrial fusion and mitochondria-dependent apoptosis by elevating Bak and Smac/Diablo and inhibiting Bcl-2. Drpitor1a inhibits proliferation in pulmonary arterial hypertension hPASMC and induces necrosis and autophagy mediators. Drpitor1a causes regression of non-small cell lung cancer tumors in mouse xenograft models and exhibits higher accumulation and efficacy in females. Drpitor1a can be used in research related to non-small cell lung cancer, myocardial ischemia-reperfusion injury, and pulmonary arterial hypertension[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Drpitor1a | 96.95% | Drpitor1a is an orally active DRP1 GTPase inhibitor. Drpitor1a blocks mitochondrial fission, inhibits DRP1 GTPase activity, and reduces ROS levels. Drpitor1a induces mitochondrial fusion and mitochondria-dependent apoptosis by elevating Bak and Smac/Diablo and inhibiting Bcl-2. Drpitor1a inhibits proliferation in pulmonary arterial hypertension hPASMC and induces necrosis and autophagy mediators. Drpitor1a causes regression of non-small cell lung cancer tumors in mouse xenograft models and exhibits higher accumulation and efficacy in females. Drpitor1a can be used in research related to non-small cell lung cancer, myocardial ischemia-reperfusion injury, and pulmonary arterial hypertension. | ||||||||||||||||||||
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References
- [1]. Chen R, et al. Targeting mitochondrial dynamics proteins for the treatment of doxorubicin-induced cardiotoxicity. Frontiers in molecular biosciences. 2023;10:1241225.
- [2]. Colpman P, et al. The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases. Cells. 2023 Jul 20;12(14):1897.
- [3]. Rozich E, et al. Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia-reperfusion injury. The Journal of physiology. 2026 Aug;604(16):6659-6674.
- [4]. Wu D, et al. Novel Drp1 GTPase Inhibitor, Drpitor1a: Efficacy in Pulmonary Hypertension. Hypertension (Dallas, Tex. : 1979). 2024 Oct;81(10):2189-2201.
