757192-67-9
757192-67-9
Chemical Structure
EN106
- CAS No.: 757192-67-9
- Formula:C13H13ClN2O3
- Molecular Weight:280.71
IUPAC Name: 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide
InChIKey: GLDJSVHDOXCYPT-UHFFFAOYSA-N
SMILES: O=C(N(CCC#N)C1=CC=C(OCCO2)C2=C1)CCl
Biological Activity: EN106 is a potent inhibitor of FEMIB. EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1. EN106 reduces oxidative stress and rescues high glucose-induced impaired angiogenesis in HUVECs[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EN106 | 99.88% | EN106 is a potent inhibitor of FEMIB. EN106 is a cysteine-reactive covalent ligand. EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1. EN106 reduces oxidative stress and rescues high glucose-induced impaired angiogenesis in HUVECs. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.61
HY-143348NJH-2-030 -
Similarity Score 0.60
HY-783344-Aminobenzo-12-crown-4 -
Similarity Score 0.59
HY-113761ASN03576800 -
Similarity Score 0.57
HY-131385KB02-COOH -
Similarity Score 0.57
HY-48955WAY-649123 -
Similarity Score 0.56
HY-165615M&B 4935 -
Similarity Score 0.56
HY-161674Monoamine Oxidase B inhibitor 4 -
Similarity Score 0.56
HY-16687BEltoprazine dihydrochloride -
Similarity Score 0.56
HY-121423RDimethachlor (Standard) -
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References
- [1]. Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022;144(2):701-708. [Content Brief]
- [2]. Zhang W, et al., Glucose-responsive, antioxidative HA-PBA-FA/EN106 hydrogel enhanced diabetic wound healing through modulation of FEM1b-FNIP1 axis and promoting angiogenesis. Bioact Mater. 2023 Jul 22;30:29-45. [Content Brief]
