796-66-7
796-66-7
Chemical Structure
5-Fluorouridine 5'-phosphate
- CAS No.: 796-66-7
- Formula:C9H12FN2O9P
- Molecular Weight:342.17
InChIKey: RNBMPPYRHNWTMA-UAKXSSHOSA-N
SMILES: O=C(N1)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=C(F)C1=O
Biological Activity: 5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a Ki value of 98 µM for human ODCase and a Ki value of 645 µM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research [1].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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5-Fluorouridine 5'-phosphate | 98.73% | 5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a Ki value of 98 µM for human ODCase and a Ki value of 645 µM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research . | ||||||||||||||||||||
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Uridine 5'-monophosphate (Standard) | 99.83% | Uridine 5'-monophosphate (Standard) is the analytical standard of Uridine 5'-monophosphate. This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea. | ||||||||||||||||||||
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5-Fluorouridine | 99.97% | 5-Fluorouridine, a metabolite of5-Fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis. | ||||||||||||||||||||
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5'-UMPS | 5'-UMPS (Uridine-5'-O-monophosphorothioate) is a P2Y14 receptor agonist. 5'-UMPS can induce HeLa cell growth slightly. | |||||||||||||||||||||
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5-F-UTP | 5-F-UTP (5-Fluorouridine-5'-triphosphate) is a monomeric raw material that can be used for nucleic acid synthesis. | |||||||||||||||||||||
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1-(b-D-Xylofuranosyl)-5-fluorouracil | 1-(b-D-Xylofuranosyl)-5-fluorouracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. | |||||||||||||||||||||
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2′-OMe-UMP | 2′-OMe-UMP is a primer extension terminator. When 2′-OMe-UMP is present at the -1 position of the primer chain, its 2′-OMe group sterically clashes with the base of the next NTP at the active site (+1 position). This clash weakens the base-stacking interaction between the +1 position and the -1 position, thereby reducing the binding affinity of the next substrate. | |||||||||||||||||||||
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OGT-719 | OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research. | |||||||||||||||||||||
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Doxifluridine | 99.44% | Doxifluridine has anticancer activity. Doxifluidine is a 5-FU prodrug. Doxifluridine is a thymidine synthase inhibitor. Doxifluridine can enhance tumor inhibition by synergizing with a variety of drugs. | ||||||||||||||||||||
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Cytidine 5'-monophosphate | 99.82% | Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide which is used as a monomer in RNA. Cytidine 5'-monophosphate consists of the nucleobase cytosine, the pentose sugar ribose, and the phosphate group. | ||||||||||||||||||||
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5-Methyluridine 5'-monophosphate | ≥97.0% | 5-Methyluridine 5'-monophosphate (Ribothymidylic acid) is a derivative of 5-Methyluridine (HY-W009444). | ||||||||||||||||||||
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