894-71-3
894-71-3
Chemical Structure
Nortriptyline hydrochloride
Synonym(s): Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
- CAS No.: 894-71-3
- Formula:C19H22ClN
- Molecular Weight:299.84
IUPAC Name: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine hydrochloride
InChIKey: SHAYBENGXDALFF-UHFFFAOYSA-N
SMILES: CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl
Biological Activity: Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
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Nortriptyline hydrochloride | 99.98% | Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects. | ||||||||||||||||||||
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Nortriptyline hydrochloride (Standard) | 99.99% | Nortriptyline (hydrochloride) (Standard) is the analytical standard of Nortriptyline (hydrochloride). This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects. | ||||||||||||||||||||
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Nortriptyline-d3 hydrochloride | 99.69% | Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression. | ||||||||||||||||||||
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References
- [1]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23. [Content Brief]
- [2]. Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. [Content Brief]
- [3]. Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20. [Content Brief]
