901-47-3
901-47-3
Chemical Structure
TAME
- CAS No.: 901-47-3
- Formula:C14H22N4O4S
- Molecular Weight:342.41
IUPAC Name: methyl tosyl-L-argininate
InChIKey: FKMJXALNHKIDOD-LBPRGKRZSA-N
SMILES: CC1=CC=C(C=C1)S(N[C@H](C(OC)=O)CCCNC(N)=N)(=O)=O
Biological Activity: TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable[1][2].
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TAME | TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable. | |||||||||||||||||||||
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References
- [1]. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. [Content Brief]
- [2]. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92. [Content Brief]
