99217-68-2
Chemical Structure
Broussochalcone A
- CAS No.: 99217-68-2
- Formula:C20H20O5
- Molecular Weight:340.37
IUPAC Name: (E)-1-(2,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
InChIKey: FEALTYYKRMRXTG-QPJJXVBHSA-N
SMILES: O=C(C1=CC(C/C=C(C)\C)=C(O)C=C1O)/C=C/C2=CC=C(O)C(O)=C2
Biological Activity: Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways[1][2].
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Broussochalcone A | 98.58% | Broussochalcone A is an antioxidant and an inhibitor of Xanthine Oxidase (IC50=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways. | ||||||||||||||||||||
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7-Hydroxy Granisetron-d3 | 7-Hydroxy Granisetron-d3 is deuterium labeled 7-Hydroxy Granisetron. | |||||||||||||||||||||
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- [1]. Cheng Z, et al. Broussochalcone A, a potent antioxidant and effective suppressor of inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Biochem Pharmacol. 2001 Apr 15;61(8):939-46. [Content Brief]
- [2]. Lee HK, et al. Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway. Oxid Med Cell Longev. 2021 Oct 27;2021:2800706. [Content Brief]
