2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. CAY10581

CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM.

For research use only. We do not sell to patients.

CAY10581 Chemical Structure

CAY10581 Chemical Structure

CAS No. : 1018340-07-2

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Based on 1 publication(s) in Google Scholar

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Description

CAY10581, a pyranonaphthoquinone derivative, is a highly specific and reversible uncompetitive IDO Inhibitor with an IC50 of 55 nM[1][2].

IC50 & Target[2]

IDO

55 nM (IC50)

In Vitro

CAY10581 (100 nM; 24 h) abrogates the growth inhibition by IFN-gamma in MSCs[1].
CAY10581 (compound 36) demonstrates minimal impact on T-REx cells viability at 100 μM after 24 h[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAY10581 Related Antibodies

Cell Viability Assay[1]

Cell Line: Mesenchymal stem cells (MSCs)
Concentration: 100 nM
Incubation Time: 24 h post-treatment
Result: Abrogated the growth inhibition by IFN-gamma (50 ng/ml) in MSCs.
Molecular Weight

363.41

Formula

C22H21NO4
CAS No.
SMILES

O=C1C2=C(C(C3=C1C=CC=C3)=O)[C@@H]([C@@H](C(C)(O2)C)O)NCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAY10581 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY105811018340-07-2CAY 10581CAY-10581Indoleamine 2,3-Dioxygenase (IDO)PyranonaphthoquinonereversibleuncompetitiveMSCsInhibitorinhibitorinhibit

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