1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. Cbl-b-IN-3

Cbl-b-IN-3 

Cat. No.: HY-141432
Handling Instructions

Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.

For research use only. We do not sell to patients.

Cbl-b-IN-3 Chemical Structure

Cbl-b-IN-3 Chemical Structure

CAS No. : 2573775-59-2

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Description

Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1].

IC50 & Target

IC50: < 1 nM (Cbl-b)[1]

In Vitro

Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

537.62

Formula

C30H34F3N5O

CAS No.
SMILES

CN1C([[email protected]@]2(C3=CC(N4CC5=C(C(F)(F)F)C=C(CN6C[[email protected]](CCC6)C)C=C5C4=O)=CC=C3)C[[email protected]](C2)C)=NN=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
Cbl-b-IN-3
Cat. No.:
HY-141432
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