1. Metabolic Enzyme/Protease
  2. E1/E2/E3 Enzyme
  3. NX-1607

NX-1607  (Synonyms: Cbl-b-IN-3)

Cat. No.: HY-141432 Purity: 99.42%
COA Handling Instructions

Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.

For research use only. We do not sell to patients.

NX-1607 Chemical Structure

NX-1607 Chemical Structure

CAS No. : 2573775-59-2

Size Price Stock Quantity
1 mg USD 500 In-stock
5 mg USD 1100 In-stock
10 mg USD 1650 In-stock
25 mg USD 3300 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1].

IC50 & Target

IC50: < 1 nM (Cbl-b)[1]

In Vitro

Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

537.62

Formula

C30H34F3N5O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1C([C@@]2(C3=CC(N4CC5=C(C(F)(F)F)C=C(CN6C[C@H](CCC6)C)C=C5C4=O)=CC=C3)C[C@H](C2)C)=NN=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (186.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8600 mL 9.3002 mL 18.6005 mL
5 mM 0.3720 mL 1.8600 mL 3.7201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8600 mL 9.3002 mL 18.6005 mL 46.5012 mL
5 mM 0.3720 mL 1.8600 mL 3.7201 mL 9.3002 mL
10 mM 0.1860 mL 0.9300 mL 1.8600 mL 4.6501 mL
15 mM 0.1240 mL 0.6200 mL 1.2400 mL 3.1001 mL
20 mM 0.0930 mL 0.4650 mL 0.9300 mL 2.3251 mL
25 mM 0.0744 mL 0.3720 mL 0.7440 mL 1.8600 mL
30 mM 0.0620 mL 0.3100 mL 0.6200 mL 1.5500 mL
40 mM 0.0465 mL 0.2325 mL 0.4650 mL 1.1625 mL
50 mM 0.0372 mL 0.1860 mL 0.3720 mL 0.9300 mL
60 mM 0.0310 mL 0.1550 mL 0.3100 mL 0.7750 mL
80 mM 0.0233 mL 0.1163 mL 0.2325 mL 0.5813 mL
100 mM 0.0186 mL 0.0930 mL 0.1860 mL 0.4650 mL
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NX-1607 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NX-1607
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HY-141432
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