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  3. PPAR
  4. Cevoglitazar

Cevoglitazar (LBM-642) is an orally active and highly potent PPARα and PPARγ dual agonist. Cevoglitazar can reduce food intake, body weight, and fasting plasma insulin in obese mice and cynomolgus monkeys. Cevoglitazar has the potential for diabetes and obesity-related disorders research.

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Cevoglitazar

Cevoglitazar Chemical Structure

CAS No. : 839673-52-8

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Based on 1 publication(s) in Google Scholar

Cevoglitazar Related Antibodies

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Description

Cevoglitazar (LBM-642) is an orally active and highly potent PPARα and PPARγ dual agonist. Cevoglitazar can reduce food intake, body weight, and fasting plasma insulin in obese mice and cynomolgus monkeys. Cevoglitazar has the potential for diabetes and obesity-related disorders research[1].

IC50 & Target[1]

PPARα

 

PPARγ

 

Molecular Weight

558.53

Formula

C27H21F3N2O6S
CAS No.
Appearance

Solid

SMILES

O=C([C@@H]1N(S(=O)(C2=CC=C(OCC3=C(C)OC(C4=CC=C(C(F)(F)F)C=C4)=N3)C=C2)=O)C5=C(C=CC=C5)C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (89.52 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7904 mL 8.9521 mL 17.9041 mL
5 mM 0.3581 mL 1.7904 mL 3.5808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7904 mL 8.9521 mL 17.9041 mL 44.7604 mL
5 mM 0.3581 mL 1.7904 mL 3.5808 mL 8.9521 mL
10 mM 0.1790 mL 0.8952 mL 1.7904 mL 4.4760 mL
15 mM 0.1194 mL 0.5968 mL 1.1936 mL 2.9840 mL
20 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2380 mL
25 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7904 mL
30 mM 0.0597 mL 0.2984 mL 0.5968 mL 1.4920 mL
40 mM 0.0448 mL 0.2238 mL 0.4476 mL 1.1190 mL
50 mM 0.0358 mL 0.1790 mL 0.3581 mL 0.8952 mL
60 mM 0.0298 mL 0.1492 mL 0.2984 mL 0.7460 mL
80 mM 0.0224 mL 0.1119 mL 0.2238 mL 0.5595 mL
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Cevoglitazar Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cevoglitazar839673-52-8LBM-642LBM642LBM 642PPARPeroxisome proliferator-activated receptorsOrallyPPARαPPARγfood intakefasting plasma insulinobesediabetesobesityInhibitorinhibitorinhibit

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