17-DMAP-GA
17-DMAP-GA, a Geldanamycin (HY-15230) analogue, is an inhibitor of HSP90. 17-DMAP-GA causes cell cycle abnormalities.
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- CAS. Nr.: 169521-68-0
- Formel: C33H50N4O8
- Molecular Weight:630.77
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-BR-3 | IC50 |
140 nM
Compound: 1b19
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Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose.
Inhibition of oncogene product p185 erbB-2 from human breast cancer cells(SK-BR-3 cells) at 50 mg/kg dose.
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[PMID: 7562911] |
Chemical Information
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CAS. Nr. 169521-68-0
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Molecular Weight 630.77
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Formel C33H50N4O8
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SMILES
CN(C)CCCNC(C(C=C1NC(/C(C)=C/C=C\[C@@H]2OC)=O)=O)=C(C[C@H](C[C@@H]([C@@H]([C@H](/C=C([C@@H]2OC(N)=O)\C)C)O)OC)C)C1=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Jurczyszyn A, et al. Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor. J Cancer. 2014;5(6):480-490. Published 2014 May 31. [Content Brief]
[2]. Tian ZQ, et al. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004;12(20):5317-5329. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
17-DMAP-GA Related Classifications
HY-136312 Related Classifications
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