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Art. -Nr.: HY-113322

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3-Hydroxyquinine

Name: 3-Hydroxyquinine
Brand: MedChemExpress
SKU: HY-113322
Price: 509.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: 3-Hydroxyquinidine)

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Based on 1 Customer Validation

3-Hydroxyquinine (3-Hydroxyquinidine) is the major metabolite of Quinine (HY-D0143) and a biomarker of CYP3A4 activity. 3-Hydroxyquinine is formed through CYP3A4-mediated 3-hydroxylation catalyzed by CYP3A isoforms.

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Reinheit : 98.13%
CAS. Nr.: 53467-23-5
Formel: C₂₀H₂₄N₂O₃
Molecular Weight:340.42

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

3-Hydroxyquinine Chemical Structure

CAS. Nr.: 53467-23-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen :

In Vitro

3-Hydroxyquinine (100-500 μM quinine; 30 min) is the major metabolite generated from quinine by human liver microsomes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 53467-23-5
Appearance Solid
Molecular Weight 340.42
Formel C₂₀H₂₄N₂O₃
Color White to off-white
SMILES

C=C[C@](C[N@@]1CC2)(O)[C@@H]2C[C@@H]1[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34
Synonyms

3-Hydroxyquinidine
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhou XY, et al. Enzymatic activities of CYP3A4 allelic variants on quinine 3-hydroxylation in vitro. Frontiers in pharmacology. 2019 May 31;10:591.

[2]. Marcsisin SR, et al. CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. Malaria journal. 2013 Jun 21;12:214.

[3]. Zhang H, et al. Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine. British journal of clinical pharmacology. 1997 Mar;43(3):245-52.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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