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Art. -Nr.: HY-153373

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4A3-Cit

Name: 4A3-Cit
Brand: MedChemExpress
SKU: HY-153373
Price: 500.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

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Reinheit : 98.04%
CAS. Nr.: 2768211-13-6
Formel: C₈₃H₁₄₇N₃O₁₆S₄
Molecular Weight:1571.33

Speicherung:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

4A3-Cit Chemical Structure

CAS. Nr.: 2768211-13-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).

In Vitro

4A3-Cit can undergo lipid fusion with endosomal membranes within the model, thereby facilitating endosomal escape. 4A3-Cit can enhance the efficiency of in vivo mRNA delivery through Selective Organ Targeting (SORT)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2768211-13-6
Appearance Oil
Molecular Weight 1571.33
Formel C₈₃H₁₄₇N₃O₁₆S₄
Color Colorless to light yellow
SMILES

O=C(CCN(CCCN(CCCN(CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)C)CCC(OCCOC(C(CSCCC(CC/C=C(C)/C)C)C)=O)=O)OCCOC(C(CSCCC(CC/C=C(C)\C)C)C)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Mol Ther

Cytosine base editing of LPA in transgenic mice averts large deletions. [Abstract]

2026 Mar 3:S1525-0016(26)00178-4. PMID: 41782368

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (63.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.6364 mL

3.1820 mL

6.3640 mL

5 mM

0.1273 mL

0.6364 mL

1.2728 mL

10 mM

0.0636 mL

0.3182 mL

0.6364 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lee SM, Cheng Q, Yu X, Liu S, Johnson LT, Siegwart DJ. A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo. Angew Chem Int Ed Engl. 2021;60(11):5848-5853. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.6364 mL	3.1820 mL	6.3640 mL	15.9101 mL
	5 mM	0.1273 mL	0.6364 mL	1.2728 mL	3.1820 mL
	10 mM	0.0636 mL	0.3182 mL	0.6364 mL	1.5910 mL
	15 mM	0.0424 mL	0.2121 mL	0.4243 mL	1.0607 mL
	20 mM	0.0318 mL	0.1591 mL	0.3182 mL	0.7955 mL
	25 mM	0.0255 mL	0.1273 mL	0.2546 mL	0.6364 mL
	30 mM	0.0212 mL	0.1061 mL	0.2121 mL	0.5303 mL
	40 mM	0.0159 mL	0.0796 mL	0.1591 mL	0.3978 mL
	50 mM	0.0127 mL	0.0636 mL	0.1273 mL	0.3182 mL
	60 mM	0.0106 mL	0.0530 mL	0.1061 mL	0.2652 mL

Bioz

Keywords

4A3-Cit

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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4A3-Cit

Publications Citing Use of MedChemExpress (MCE) 4A3-Cit