Art. -Nr.: HY-10257

BAY 11-7085

(Synonyms: BAY 11-7083)

51 Cited Publications

Kundenbewertung

Based on 51 publication(s) in Google Scholar

BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC₅₀ of 10 μM.

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Reinheit: 99.96%
CAS. Nr.: 196309-76-9
Formel: C₁₃H₁₅NO₂S
Molecular Weight:249.33

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

BAY 11-7085 Chemical Structure

CAS. Nr.: 196309-76-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (51)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC₅₀ of 10 μM^[1].

IC₅₀ & Target^[1]

NF-κB

IκB-α

10 μM (IC₅₀)

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	EC₅₀	2.6 μM Compound: 1	Cytotoxicity against human A2780 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control Cytotoxicity against human A2780 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control	[PMID: 25581261]
A2780	IC₅₀	2.6 μM Compound: 1, BAY-117085	Antitumor activity against human A2780 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay Antitumor activity against human A2780 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay	[PMID: 22326395]
BXPC-3	EC₅₀	3.5 μM Compound: 1	Cytotoxicity against human BxPC3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control Cytotoxicity against human BxPC3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control	[PMID: 25581261]
BXPC-3	IC₅₀	3.7 μM Compound: 1, BAY-117085	Antitumor activity against human BxPC3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay Antitumor activity against human BxPC3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay	[PMID: 22326395]
DBTRG-05MG	IC₅₀	5.53 μM Compound: 49; BAY 11-7085	Cytotoxicity against human DBTRG-05MG cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay Cytotoxicity against human DBTRG-05MG cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay	[PMID: 36332549]
HeLa	IC₅₀	0.1 μM Compound: BAY-117085	Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation	[PMID: 17845850]
MDA-MB-231	IC₅₀	4.31 μM Compound: 49; BAY 11-7085	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 24 hrs by sulforhodamine B assay	[PMID: 36332549]
SK-OV-3	EC₅₀	5 μM Compound: 1	Cytotoxicity against human SKOV3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control Cytotoxicity against human SKOV3 cells co-cultured with human mesothelial cells after 4 hrs by firefly luciferase assay relative to control	[PMID: 25581261]
SK-OV-3	IC₅₀	7.6 μM Compound: 1, BAY-117085	Antitumor activity against human SKOV3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay Antitumor activity against human SKOV3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay	[PMID: 22326395]

In Vitro

BAY 11-7085 inhibits TNFa-induced surface expression of E-selectin, VCAM-1, and ICAM-1with IC₅₀ values in the range of 5-10 μM. BAY 11-7085 stabilizes IκBα in a dose-dependent manner with an IC₅₀ value of approximately 10 μM. There is a clear correlation between the concentration of drug that stabilized IκBα, the concentration that inhibits nuclear levels of NF-kB, and the concentration that inhibits adhesion molecule expression^[1].
BAY 11-7085 has been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. BAY 11-7085 (ECSCs) significantly inhibits the cell proliferation and DNA synthesis of ovarian endometriotic cyst stromal cells and induces apoptosis and the G0/G1 phase cell cycle arrest of these cells. BAY 11-7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins, and that caspase-3-, -8-, and -9-mediated cascades are involved in this mechanism^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BAY 11-7085 acts as an anti-inflammatory agent in both the rat carrageenan paw and the rat adjuvant arthritis model. It demonstrates a dose-dependent reduction in swelling in the rat carrageenan paw model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 196309-76-9
Appearance Solid
Molecular Weight 249.33
Formel C₁₃H₁₅NO₂S
Color White to off-white
SMILES

N#C/C=C/S(C(C=C1)=CC=C1C(C)(C)C)(=O)=O
Synonyms

BAY 11-7083
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (51)

All Bio/Physico-chemical AssayWBFlow CytometryCell Imaging/StainingCell Proliferation/Viability Assay

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Journal Impact Factor

Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Cancer Cell

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity. [Abstract]

2024 Dec 9;42(12):2015-2031.e11. PMID: 39577420
Cell Host Microbe

Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy. [Abstract]

2025 Jun 11;33(6):915-931.e9. PMID: 40441145
Hepatology

A hMTR4-PDIA3P1-miR-125/124-TRAF6 Regulatory Axis and Its Function in NF kappa B Signaling and Chemoresistance. [Abstract]

2020 May;71(5):1660-1677. PMID: 31509261
Carbohydr Polym

Insights into oral lentinan immunomodulation: Dectin-1-mediated lymphatic transport from Peyer's patch M cells to mononuclear phagocytes. [Abstract]

2024 Dec 15:346:122586. PMID: 39245482

BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]

BAY 11-7085 (5 μM/mL; 30 min) in Caco-2 cells showed that the integrity of the monolayer was preserved during inhibitor and FLNT coincubation.

BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]

BAY 11-7085 (5 μM/mL; 30 min) followed by incubation with 200 μg/mL FLNT for 2 h inhibited the uptake of FLNT by 19.7 %. Flow cytometric analysis of the cellular uptake of FLNT by BMDCs treated with Dectin-1/Syk/NF-κB pathway inhibitors.

BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Carbohydr Polym. 2024 Dec 15:346:122586. [Abstract]

BAY 11-7085 (5 μM/mL; 30 min) followed by incubation with 200 μg/mL FLNT for 2 h inhibited the uptake of FLNT by 19.7 %. CLSM images of the cellular uptake of FLNT by BMDCs treated with Dectin-1/Syk/NF-κB pathway inhibitors.
Cell Death Dis

A small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors. [Abstract]

2020 Nov 15;11(11):982. PMID: 33191401

BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 15;11(11):982. [Abstract]

BAY 11-7085 (bay; 20 μM; 48 h) in SW620 cells, Protein levels of the key transcription factors and master regulators in mTOR signaling and its downstream targets, translation initiation factors, anti-apoptotic proteins, and cancer stemness-related proteins.

BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Nov 15;11(11):982. [Abstract]

Relative mRNA levels of key transcription factors, master regulators in mTOR signaling and its downstream targets, translation initiation factors, anti-apoptotic proteins, and cancer stemness-related proteins in SW620 cells treated with CADPE (12.5 μM) or FBR for 24 h (n = 3). FBR: a combination of 10058-F4 (30 μM), Bay 11-7085 (20 μM), and Ruxolitinib (20 μM).
Cell Commun Signal

Netrin-1-UNC5B/neogenin axis enhances the stemness of colorectal cancer cells. [Abstract]

2025 Nov 13;23(1):496. PMID: 41233873
Phytomedicine

Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-α stimulation by inhibiting Notch1-Jagged1/NF-κB(p65) signaling. [Abstract]

2024 Jan:123:154928. PMID: 38043386
Phytomedicine

Total flavone of flowers of Abelmoschus manihot (L.) Medic inhibits the expression of adhesion molecules in primary mesenteric arterial endothelial cells and ameliorates dextran sodium sulphate-induced ulcerative colitis in mice. [Abstract]

2023 Apr:112:154713. PMID: 36857970
Cell Chem Biol

Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses. [Abstract]

2022 Jul 21;29(7):1113-1125.e6. PMID: 35728599
Cell Mol Gastroenterol Hepatol

USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-κB Signaling in Macrophages. [Abstract]

2022;14(5):1103-1122. PMID: 35934222
Cell Rep

Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection. [Abstract]

2022 Apr 19;39(3):110698. PMID: 35443182
Br J Pharmacol

Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ. [Abstract]

2021 Jun;178(12):2443-2460. PMID: 33661551
Chin Med

Grain-sized moxibustion activates dendritic cells to enhance the antitumor immunity of cancer vaccines. [Abstract]

2025 May 27;20(1):73. PMID: 40426190
Front Immunol

Monocarboxylate Transporter 4 Triggered Cell Pyroptosis to Aggravate Intestinal Inflammation in Inflammatory Bowel Disease. [Abstract]

2021 May 19:12:644862. PMID: 34093533
Sci Signal

TSHZ2 is an EGF-regulated tumor suppressor that binds to the cytokinesis regulator PRC1 and inhibits metastasis. [Abstract]

2021 Jun 22;14(688):eabe6156. PMID: 34158398
J Ethnopharmacol

Ginsenoside Rg1 restores energy homeostasis in glucolipid metabolic disorders by modulating hypothalamic neuroinflammation. [Abstract]

2026 May 26:121901. PMID: 42202919
Food Front

2025 Oct 7.
Food Biosci

2025 Jun.
Inflamm Res

Lipopolysaccharide (LPS) induces sclerostin secretion by extracellular vesicle via TLR4/miR-92a-3p/PTEN/NF-κB signalling pathway in murine macrophage. [Abstract]

2025 Jan 25;74(1):27. PMID: 39862242
Cell Biol Toxicol

TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways. [Abstract]

2021 Apr;37(2):313-330. PMID: 32535744
J Hypertens

KAT7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-κB signaling pathway. [Abstract]

2025 May 1;43(5):827-840. PMID: 40084466
Int J Mol Sci

iE-DAP Induced Inflammatory Response and Tight Junction Disruption in Bovine Mammary Epithelial Cells via NOD1-Dependent NF-κB and MLCK Signaling Pathway. [Abstract]

2023 Mar 27;24(7):6263. PMID: 37047240
Int J Mol Sci

Psoriasis-Associated Inflammatory Conditions Induce IL-23 mRNA Expression in Normal Human Epidermal Keratinocytes. [Abstract]

2022 Jan 4;23(1):540. PMID: 35008970
Int Immunopharmacol

BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization. [Abstract]

2021 Jul:96:107591. PMID: 33812253
Int Immunopharmacol

Secoisolariciresinol diglucoside suppresses Dextran sulfate sodium salt-induced colitis through inhibiting NLRP1 inflammasome. [Abstract]

2020 Jan;78:105931. PMID: 31812068
Int J Mol Sci

Differential Inflammatory-Response Kinetics of Human Keratinocytes upon Cytosolic RNA- and DNA-Fragment Induction. [Abstract]

2018 Mar 8;19(3). pii: E774. PMID: 29518010
Am J Respir Cell Mol Biol

Airway Epithelium-derived CXCL14 Promotes Eosinophil Accumulation in Allergic Airway Inflammation. [Abstract]

2025 Feb;72(2):145-157. PMID: 39141567
Arthritis Res Ther

Methotrexate promotes the release of granulocyte-macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling. [Abstract]

2024 Oct 11;26(1):178. PMID: 39394168
Food Sci Nutr

Anti-inflammatory actions of acetate, propionate, and butyrate in fetal mouse jejunum cultures ex vivo and immature small intestinal cells in vitro. [Abstract]

2022 Jan 18;10(2):564-576. PMID: 35154692
Mol Med Rep

Upregulation of RIP3 promotes necroptosis via a ROS‑dependent NF‑κB pathway to induce chronic inflammation in HK‑2 cells. [Abstract]

2021 Nov;24(5):783. PMID: 34498705
PLoS Pathog

AHR is a tunable knob that controls HTLV-1 latency-reactivation switching. [Abstract]

2020 Jul 17;16(7):e1008664. PMID: 32678826

BAY 11-7085 purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2020 Jul 17;16(7):e1008664. [Abstract]

HPB-ATL-T, MT-2, MT-4, TL-Om1 cells were treated with BAY11-7085 (2.5, 5 μM) or DMSO for 24 h. Treatment with BAY11-7085 significantly impairs AHR expression in these four cell lines.
Oncol Rep

NF‑κB‑driven LUZP1 promotes metastasis and chemoresistance in head and neck squamous cell carcinoma. [Abstract]

2026 Jun;55(6):110. PMID: 41952496
J Dairy Sci

Sodium butyrate promotes lipopolysaccharide-induced innate immune responses by enhancing mitogen-activated protein kinase activation and histone acetylation in bovine mammary epithelial cells. [Abstract]

2020 Dec;103(12):11636-11652. PMID: 33010913
J Inflamm Res

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway. [Abstract]

2022 Feb 15;15:1027-1046. PMID: 35210810
iScience

Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition. [Abstract]

2024 May 16;27(6):110011. PMID: 38868181
Neurochem Res

The Role of NF-κB/NLRP3 Inflammasome Signaling Pathway in Attenuating Pyroptosis by Melatonin Upon Spinal Nerve Ligation Models. [Abstract]

2022 Feb;47(2):335-346. PMID: 34515922
J Virol

The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling. [Abstract]

2025 Dec 23;99(12):e0108925. PMID: 41334925
BMC Cancer

Azelaic acid attenuates CCL2/CCR2 axis-mediated skin trafficking of acute myeloid leukemia cells through NF-κB/MAPK signaling modulation in keratinocytes. [Abstract]

2025 Jul 31;25(1):1250. PMID: 40745589
Microbiol Spectr

Tp47-Induced Monocyte-Derived Microvesicles Promote the Adherence of THP-1 Cells to Human Umbilical Vein Endothelial Cells via an ERK1/2-NF-κB Signaling Cascade. [Abstract]

2023 Aug 17;11(4):e0188823. PMID: 37382544
Lab Invest

IL-1α and IL-1β promote NOD2-induced immune responses by enhancing MAPK signaling. [Abstract]

2019 Sep;99(9):1321-1334. PMID: 31019287
Toxins

Lipopolysaccharide from the Cyanobacterium Geitlerinema sp. Induces Neutrophil Infiltration and Lung Inflammation. [Abstract]

2022 Apr 9;14(4):267. PMID: 35448876
Epigenetics

IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway. [Abstract]

2023 Dec;18(1):2265625. PMID: 37871286
Exp Eye Res

Proteomic characterization of aqueous humor in corneal endothelial decompensation after penetrating keratoplasty. [Abstract]

2023 May:230:109457. PMID: 36948439
Front Vet Sci

Anti-inflammatory Effect of Astragalin and Chlorogenic Acid on Escherichia coli-Induced Inflammation of Sheep Endometrial Epithelium Cells. [Abstract]

2020 Apr 30:7:201. PMID: 32426380
Physiol Res

RPS3 Aggravates Sepsis-Induced Acute Kidney Injury Through Activating NF-kappaB Mediated Renal Inflammatory Responses. [Abstract]

2026 Mar 11;75(1):63-77. PMID: 41811702
PLoS One

Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation. [Abstract]

2025 Nov 20;20(11):e0336901. PMID: 41264606
Cell Physiol Biochem

Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome. [Abstract]

2017;43(5):1855-1865. PMID: 29049992

BAY 11-7085 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;43(5):1855-1865. [Abstract]

Elevated SOD activity and HO-1 mRNA expression, and reduced CAT activity induced by LPS are inhibited by BAY 11-7085.
Exp Ther Med

LncRNA MIR4435-2HG inhibits the progression of osteoarthritis through miR-510-3p sponging. [Abstract]

2020 Aug;20(2):1693-1701. PMID: 32742398
Res Sq

2025 Aug 11.
Research Square Preprint

2021 Feb.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (501.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.0107 mL

20.0537 mL

40.1075 mL

5 mM

0.8021 mL

4.0107 mL

8.0215 mL

10 mM

0.4011 mL

2.0054 mL

4.0107 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (8.34 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

Cell Assay^[2]

ECSCs cells are incubated for 48 h with BAY 11-7085 (0.01-10 μM). Thereafter, 20 μL of WST-1 dye are added to each well, and the cells are further incubated for 4 h. All experiments are performed in the presence of 10% FBS. Cell proliferation is evaluated by measuring absorbance at 540 nm^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[1]

Rats: 1% suspension of carrageenan in distilled water is administered to rats as 0.1 mL subplantar injection into the footpad of the right hind paw. One hour prior to injection, rats are treated intraperitoneally with vehicle (polyethylglycol 400 diluted 1:5 in 5% bovine serum albumin/water) or a fine suspension of compound 2 (1, 5, or 50 mg/kg) in vehicle. A positive control group is also included in which rats are pretreated with 20 mg/kg ibuprofen. Four hours after carrageenan administration, the volume of the injected paw is measured. Edema volumes are determined^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesionmolecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103. [Content Brief]

[2]. Nasu K, et al. Application of the nuclear factor-kappaB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E16-23. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.0107 mL	20.0537 mL	40.1075 mL	100.2687 mL
	5 mM	0.8021 mL	4.0107 mL	8.0215 mL	20.0537 mL
	10 mM	0.4011 mL	2.0054 mL	4.0107 mL	10.0269 mL
	15 mM	0.2674 mL	1.3369 mL	2.6738 mL	6.6846 mL
	20 mM	0.2005 mL	1.0027 mL	2.0054 mL	5.0134 mL
	25 mM	0.1604 mL	0.8021 mL	1.6043 mL	4.0107 mL
	30 mM	0.1337 mL	0.6685 mL	1.3369 mL	3.3423 mL
	40 mM	0.1003 mL	0.5013 mL	1.0027 mL	2.5067 mL
	50 mM	0.0802 mL	0.4011 mL	0.8021 mL	2.0054 mL
	60 mM	0.0668 mL	0.3342 mL	0.6685 mL	1.6711 mL
	80 mM	0.0501 mL	0.2507 mL	0.5013 mL	1.2534 mL
	100 mM	0.0401 mL	0.2005 mL	0.4011 mL	1.0027 mL

Keywords

BAY 11-7085

51 Cited Publications

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BAY 11-7085

Apoptosis Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Pyroptosis Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Transcription Factor-Targeted Library

Anti-Liver Cancer Compound Library

Antidepressant Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Cysteine Targeted Covalent Library

Cysteine Targeted Covalent Fragment Library

Cell Death Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Fibrosis Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) BAY 11-7085

Alle NF-κB Isoform-spezifische Produkte anzeigen

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Publications (51)

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Protokoll

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Complete Stock Solution Preparation Table

BAY 11-7085 Related Classifications

HY-10257 Related Classifications