Art. -Nr.: HY-B0415

Fluocinolone (Acetonide)

1 Cited Publications

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Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015).

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Reinheit: 99.68%
CAS. Nr.: 67-73-2
Formel: C₂₄H₃₀F₂O₆
Molecular Weight:452.49

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Fluocinolone (Acetonide) Chemical Structure

CAS. Nr.: 67-73-2

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vitro

Fluocinolone (0.1-50 μg/mL, 2 days) improves foam cell survival in THP-1 cells^[1].
Fluocinolone (0.1-50 μg/mL, 2 days) inhibits infammatory cytokines secretion and reduces cholesteryl ester accumulation^[1].
Fluocinolone (0.1-100 μmol/L, 24 h) promotes the proliferation of DPCs^[2].
Fluocinolone (1-10 μmol/L, 7 days) promotes the expressions of BSP, OCN, DSPP, and Wnt4, and up-regulates Wnt4 and the dentin-specific marker dentin sialophosphoprotein^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

DCPs
Concentration:

0.1 μmol/L, 1 μmol/L, 10 μmol/L, 20 μmol/L, 40 μmol/L, 60 μmol/L, 100 μmol/L
Incubation Time:

24 h
Result:

Significantly promoted the growth rate of DPCs of a low concentration.

Western Blot Analysis^[2]

Cell Line:

DCPs
Concentration:

1 μmol/L, 10 μmol/L
Incubation Time:

7 days
Result:

Showed higher expressions of DSPP and Wnt4 protein than negative control.

In Vivo

Fluocinolone (500 μg/kg, Intraperitoneal injection, once a day for 2 weeks) prevents development of significant peripheral neuropathy in a mouse model of PTX-induced^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PTX-induced peripheral neuropathy model ^[3]
Dosage:

500 μg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Prevented a marked reduction in intraepidermal nerve fibers density in the plantar surface of the hind paws.

Chemical Information

CAS. Nr. 67-73-2
Appearance Solid
Molecular Weight 452.49
Formel C₂₄H₃₀F₂O₆
Color White to off-white
SMILES

O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C5)(OC(C)(C)O1)[C@]25C)CO
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Drug Deliv Transl Res

Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]

2025 Oct 29. PMID: 41160380

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (221.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2100 mL

11.0500 mL

22.0999 mL

5 mM

0.4420 mL

2.2100 mL

4.4200 mL

10 mM

0.2210 mL

1.1050 mL

2.2100 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.60 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (393 KB)
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- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
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- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nguyen L T H, et al. The potential of fluocinolone acetonide to mitigate inflammation and lipid accumulation in 2D and 3D foam cell cultures [J]. BioMed Research International, 2018, 2018.

[2]. Liu Z, et al. Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells [J]. Journal of endodontics, 2013, 39(2): 217-222.

[3]. Cetinkaya-Fisgin A, et al. Identification of fluocinolone acetonide to prevent paclitaxel‐induced peripheral neuropathy [J]. Journal of the Peripheral Nervous System, 2016, 21(3): 128-133.

[4]. Nehmé A, et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells [J]. BMC medical genomics, 2009, 2(1): 1-14.

[5]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide

[6]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2100 mL	11.0500 mL	22.0999 mL	55.2498 mL
	5 mM	0.4420 mL	2.2100 mL	4.4200 mL	11.0500 mL
	10 mM	0.2210 mL	1.1050 mL	2.2100 mL	5.5250 mL
	15 mM	0.1473 mL	0.7367 mL	1.4733 mL	3.6833 mL
	20 mM	0.1105 mL	0.5525 mL	1.1050 mL	2.7625 mL
	25 mM	0.0884 mL	0.4420 mL	0.8840 mL	2.2100 mL
	30 mM	0.0737 mL	0.3683 mL	0.7367 mL	1.8417 mL
	40 mM	0.0552 mL	0.2762 mL	0.5525 mL	1.3812 mL
	50 mM	0.0442 mL	0.2210 mL	0.4420 mL	1.1050 mL
	60 mM	0.0368 mL	0.1842 mL	0.3683 mL	0.9208 mL
	80 mM	0.0276 mL	0.1381 mL	0.2762 mL	0.6906 mL
	100 mM	0.0221 mL	0.1105 mL	0.2210 mL	0.5525 mL

Keywords

Fluocinolone (Acetonide)

1 Cited Publications

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Fluocinolone (Acetonide)

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Publications Citing Use of MedChemExpress (MCE) Fluocinolone (Acetonide)

Alle Wnt Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Fluocinolone (Acetonide)

Immunology/Inflammation Compound Library

Stem Cell Signaling Compound Library

Wnt/Hedgehog/Notch Compound Library

FDA-Approved Drug Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Endocrinology Compound Library

Cytoskeleton Compound Library

FDA Approved & Pharmacopeial Drug Library

Neuroprotective Compound Library

Nuclear Receptor Compound Library

Non-steroidal Anti-Inflammatory Compound Library

Pain-Related Compound Library

Off-patent Drug Library

Extracellular Vesicles (EVs) Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Fluocinolone (Acetonide)

Alle Wnt Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Fluocinolone (Acetonide) Related Classifications

HY-B0415 Related Classifications