Pipequaline
Based on 1 publication(s) in Google Scholar
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.93%
- CAS. Nr.: 77472-98-1
- Formel: C22H24N2
- Molecular Weight:316.44
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Publications Citing Use of MedChemExpress (MCE) Pipequaline
More
Biologische Aktivität
Benzodiazepine receptor[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 77472-98-1
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Appearance Solid
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Molecular Weight 316.44
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Formel C22H24N2
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Color White to off-white
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SMILES
C1(C2=CC=CC=C2)=NC3=CC=CC=C3C(CCC4CCNCC4)=C1
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Synonyms
PK-8165
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Bioorg Chem
Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]2024 Jun:147:107412. PMID: 38696845
Lösungsmittel & Löslichkeit
DMSO : ≥ 32 mg/mL (101.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Bradwejn J, et al. Effects of PK 8165, a partial benzodiazepine receptor agonist, on cholecystokinin-inducedactivation of hippocampal pyramidal neurons: a microiontophoretic study in the rat. Eur J Pharmacol. 1985 Jun 19;112(3):415-8. [Content Brief]
[2]. Debonnel G, et al. Pipequaline acts as a partial agonist of benzodiazepine receptors: an electrophysiological study in the hippocampus of the rat. Neuropharmacology. 1987 Sep;26(9):1337-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1602 mL | 15.8008 mL | 31.6016 mL | 79.0039 mL |
| 5 mM | 0.6320 mL | 3.1602 mL | 6.3203 mL | 15.8008 mL | |
| 10 mM | 0.3160 mL | 1.5801 mL | 3.1602 mL | 7.9004 mL | |
| 15 mM | 0.2107 mL | 1.0534 mL | 2.1068 mL | 5.2669 mL | |
| 20 mM | 0.1580 mL | 0.7900 mL | 1.5801 mL | 3.9502 mL | |
| 25 mM | 0.1264 mL | 0.6320 mL | 1.2641 mL | 3.1602 mL | |
| 30 mM | 0.1053 mL | 0.5267 mL | 1.0534 mL | 2.6335 mL | |
| 40 mM | 0.0790 mL | 0.3950 mL | 0.7900 mL | 1.9751 mL | |
| 50 mM | 0.0632 mL | 0.3160 mL | 0.6320 mL | 1.5801 mL | |
| 60 mM | 0.0527 mL | 0.2633 mL | 0.5267 mL | 1.3167 mL | |
| 80 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9875 mL | |
| 100 mM | 0.0316 mL | 0.1580 mL | 0.3160 mL | 0.7900 mL |
Pipequaline Related Classifications
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