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Art. -Nr.: HY-12114

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Serlopitant

Name: Serlopitant
Brand: MedChemExpress
SKU: HY-12114
Availability: PreOrder

(Synonyms: VPD-737; MK-0594)

Serlopitant (VPD-737) is an orally active Neurokinin 1 receptor antagonist. Serlopitant inhibits pruritus signal transduction via NK receptors in spinal neurons and brain regions, and blocks the efferent function of substance P in the skin. Serlopitant can be used in research related to chronic pruritus, prurigo nodularis, and pruritus associated with psoriasis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 860642-69-9
Formel: C₂₉H₂₈F₇NO₂
Molecular Weight:555.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Serlopitant Chemical Structure

CAS. Nr.: 860642-69-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

NK1R

Alle Neurokinin Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	0.06 nM Compound: 17	Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in absence of human serum albumin	[PMID: 19354254]
CHO	IC₅₀	0.06 nM Compound: 2	Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells	[PMID: 23808489]
CHO	IC₅₀	9.5 nM Compound: 17	Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin Displacement of [125I]substance P human recombinant NK1 receptor expressed in CHO cells in presence of human serum albumin	[PMID: 19354254]
CHO	IC₅₀	9.5 nM Compound: 2	Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serum	[PMID: 23808489]

In Vitro

Serlopitant induces a dose-dependent reduction in chronic pruritus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 860642-69-9
Molecular Weight 555.53
Formel C₂₉H₂₈F₇NO₂
SMILES

O=C1C=C(N2C[C@@]3([H])CC[C@H](O[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)[C@@H](C5=CC=C(F)C=C5)[C@]3([H])C2)CC1
Synonyms

VPD-737; MK-0594
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yosipovitch G, et al. Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial. J Am Acad Dermatol. 2018 May;78(5):882-891.e10. [Content Brief]

[2]. Ständer S, et al. The NK1 receptor antagonist serlopitant for treatment of chronic pruritus. Expert opinion on investigational drugs. 2019 Aug;28(8):659-666.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise

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Vofopitant dihydrochloride

Netupitant

Senktide

Fezolinetant

Rolapitant

Fosaprepitant dimeglumine

Talnetant

NKP608

Pavinetant

Tradipitant

Maropitant

Ibodutant

Alle Neurokinin Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Serlopitant Related Classifications

HY-12114 Related Classifications

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