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Art. -Nr.: HY-182332

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AChE-IN-111

AChE-IN-111 is an acetylcholinesterase inhibitor with a IC₅₀ of 0.37 μM. AChE-IN-111 scavenges various reactive oxygen and nitrogen species. AChE-IN-111 exhibits significant antioxidant potential and iron regulatory protein levels. AChE-IN-111 can be used for the research of Alzheimer's disease.

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Formel: C₂₆H₂₆N₄O₇S
Molecular Weight:538.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE-IN-111 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

AChE-IN-111 (Compound 4q) (62.5 μg/mL) exhibits weak inhibitory activity against butyrylcholinesterase, with an inhibition rate of 33.6%^[1].
AChE-IN-111 (10 μg/mL) exhibits potent in vitro antioxidant potential, with a total antioxidant capacity of 83.05 mg gallic acid/g and an IRP level of 123.4 μM^[1].
AChE-IN-111 (10 μg/mL) exhibits in vitro antioxidant and free radical scavenging activities against DPPH, ABTS, NO, OH and H₂O₂ free radicals, with IC₅₀ values of 11.38, 9.88, 14.45, 18.68 and 21.15 μM, respectively^[1].
AChE-IN-111 exhibits CYP450 inhibitory activity, with inhibitory effects on CYP2C19, CYP2C9, and CYP3A4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 538.57
Formel C₂₆H₂₆N₄O₇S
SMILES

CCS(=O)(OC1=CC(/C=N/NC(COC2=CC=C(C3=NC4=CC=CC=C4N3)C=C2OC)=O)=CC=C1OC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Omar MA, et al. New benzimidazole-alkanesulfonate conjugates as cholinesterase inhibitors with in vitro and in silico validation. Sci Rep. 2026;16(1):8946. Published 2026 Mar 12. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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AChE-IN-111

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen