AChE-IN-119
AChE-IN-119 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.0641 μM and a Ki of 0.01648 μM. AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals. AChE-IN-119 exhibits mixed-type inhibition and interacts with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. AChE-IN-119 can be used for the research of Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C20H13ClN4O2S
- Molecular Weight:408.86
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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AChE 0.01648 μM (Ki) |
AChE 0.0641 μM (IC50) |
AChE-IN-119 (compound 4) potently inhibits purified acetylcholinesterase (AChE) via a mixed-type inhibition mechanism, with an IC50 of 0.0641 μM. It exhibits 108-fold higher selectivity for AChE over butyrylcholinesterase (BChE), and its Ki value against AChE is 0.01648 μM[1].
AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals, with an IC50 of 10.01 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 408.86
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Formel C20H13ClN4O2S
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SMILES
CN(C1=CC=C(Cl)C=C1/C2=N/NC3=NC=C(C4=CC(C=CC=C5)=C5O4)S3)C2=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AChE-IN-119 Related Classifications
HY-184796 Related Classifications
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