AChE-IN-28
AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase with an IC50 of 0.2 nM.
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- Formel: C33H48BrF3N5O4
- Molecular Weight:715.66
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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AChE 0.2 nM (IC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Wistar rats, experimental autoimmune model of myasthenia gravis (EAMG)[1]
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Dosage:0.005, 0.01, 0.015 and 0.1 mg/kg
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Administration:Intraperitoneal injection, single dose
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Result:The dose that restored the value of decrement of amplitude of APs in animals with EAMG to the level of control rats was 0.01 mg/kg. Showed a long lasting effect and had no significant effect on the force of urinary bladder contractions in animals with EAMG.
Chemical Information
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Molecular Weight 715.66
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Formel C33H48BrF3N5O4
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SMILES
CC[N+](CCCCCN1C(C=CN(C1=O)CCCCCCN(C(C=C2=O)C)C(N2C)=O)=O)(CC3=CC=CC=C3C(F)(F)F)CC.[Br-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AChE-IN-28 Related Classifications
HY-151927 Related Classifications
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