AI-10-47
Based on 1 publication(s) in Google Scholar
AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.17%
- CAS. Nr.: 1256094-31-1
- Formel: C13H8F3N3O
- Molecular Weight:279.22
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) AI-10-47
More
Biologische Aktivität
AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding[1].
AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4 × 106 SEM cells.
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Concentration:10 μM.
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Incubation Time:6 h.
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Result:Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
Chemical Information
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CAS. Nr. 1256094-31-1
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Appearance Solid
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Molecular Weight 279.22
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Formel C13H8F3N3O
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Color Off-white to gray
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SMILES
FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
Cannabidiol mitigates radiation-induced intestine ferroptosis via facilitating the heterodimerization of RUNX3 with CBFβ thereby promoting transactivation of GPX4. [Abstract]2024 Jun 1:S0891-5849(24)00506-9. PMID: 38830513
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (358.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5814 mL | 17.9070 mL | 35.8141 mL | 89.5351 mL |
| 5 mM | 0.7163 mL | 3.5814 mL | 7.1628 mL | 17.9070 mL | |
| 10 mM | 0.3581 mL | 1.7907 mL | 3.5814 mL | 8.9535 mL | |
| 15 mM | 0.2388 mL | 1.1938 mL | 2.3876 mL | 5.9690 mL | |
| 20 mM | 0.1791 mL | 0.8954 mL | 1.7907 mL | 4.4768 mL | |
| 25 mM | 0.1433 mL | 0.7163 mL | 1.4326 mL | 3.5814 mL | |
| 30 mM | 0.1194 mL | 0.5969 mL | 1.1938 mL | 2.9845 mL | |
| 40 mM | 0.0895 mL | 0.4477 mL | 0.8954 mL | 2.2384 mL | |
| 50 mM | 0.0716 mL | 0.3581 mL | 0.7163 mL | 1.7907 mL | |
| 60 mM | 0.0597 mL | 0.2985 mL | 0.5969 mL | 1.4923 mL | |
| 80 mM | 0.0448 mL | 0.2238 mL | 0.4477 mL | 1.1192 mL | |
| 100 mM | 0.0358 mL | 0.1791 mL | 0.3581 mL | 0.8954 mL |
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