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Art. -Nr.: HY-P12411

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Asn-Trp

Asn-Trp is an orally active antioxidant dipeptide. Asn-Trp inhibits oxidative stress, lipid peroxidation, and advanced glycation end product formation. Asn-Trp improves spatial memory and learning dysfunction. Asn-Trp can be obtained by computer-aided simulated hydrolysis of the yam tuber storage protein Dioscorin by pepsin (Pepsin) (HY-P1635), and can be detected in the pepsin hydrolysate by mass spectrometry after reversed-phase HPLC fractionation.

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CAS. Nr.: 74105-03-6
Formel: C₁₅H₁₈N₄O₄
Molecular Weight:318.33

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Asn-Trp Chemical Structure

CAS. Nr.: 74105-03-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Oxidative StressOthers

Oxidative Stress

Asn-Trp (50-100 μM) scavenges hydroxyl radicals in the ESR/DMPO Fenton system, with scavenging activity reaching 88.8% at 100 μM^[1].
Asn-Trp (50-100 μM; 0-4 h) protects rat erythrocytes from AAPH (HY-Y0525)-mediated hemolysis, with 83.6% protective activity at 100 μM^[1].

Others

Asn-Trp (50-100 μM; 10 days) inhibits CML formation in the BSA/galactose model, reducing relative CML density to 14.8% at 100 μM^[1].
Asn-Trp (50-100 μM; 10 days) inhibits CML formation in the BSA/glucose model, reducing relative CML density to 58.8% at 100 μM^[1].
Asn-Trp (50-200 μM; 24 h) protects HUVECs from MGO-induced cell death, restoring viability to 101% at 200 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human umbilical vein endothelial cells (HUVECs)
Concentration:

50, 100, and 200 μM
Incubation Time:

24 h (pre-incubation); 24 h (MGO exposure)
Result:

At 50-200 μM, did not reduce HUVEC viability.
MGO exposure decreased HUVEC viability to about 53.4%.
Pre-incubation recovered cell viability to 70.9% at 50 μM, 85.7% at 100 μM, and 101% at 200 μM.

In Vivo

Oxidative Stress

Asn-Trp (40 mg/kg/day; p.o.; daily; 4 weeks) improves D-galactose (HY-N0210)-induced spatial learning/memory deficits and oxidative stress in BALB/c mice, while 10-40 mg/kg/day reduces plasma and tissue oxidative damage markers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 10 weeks old)^[1]
Dosage:

10 mg/kg/day; 40 mg/kg/day
Administration:

p.o.; daily; 4 weeks
Result:

Plasma MDA at 8 weeks was lower in the 10 mg/kg/day and 40 mg/kg/day groups than in the Gal group.
In the Morris water maze reference memory task, 40 mg/kg/day reduced latency to reach the platform compared with Gal, with latency comparable to blank; 10 mg/kg/day did not.
Swimming speed was comparable across groups.
In the probe trial, 40 mg/kg/day increased crossings in the target quadrant compared with Gal, with crossings comparable to blank; 10 mg/kg/day did not.
Brain GSH was elevated by 40 mg/kg/day versus Gal; liver GSH was elevated by 10 mg/kg/day and 40 mg/kg/day versus Gal.
Brain MDA was reduced by 10 mg/kg/day and 40 mg/kg/day versus Gal and was comparable to blank; liver MDA was reduced by 40 mg/kg/day versus Gal.
ORAC activity in brain and liver tissues was elevated by 10 mg/kg/day and 40 mg/kg/day versus Gal.
40 mg/kg/day reduced argpyrimidine-modified AGEs in brain tissue versus Gal; 10 mg/kg/day and 40 mg/kg/day reduced CML-modified AGEs in brain tissue versus Gal, comparable to blank.

Related Protocols :

Chemical Information

CAS. Nr. 74105-03-6
Molecular Weight 318.33
Formel C₁₅H₁₈N₄O₄
Sequence

Asn-Trp
Sequence Shortening

NW
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Han CH, et al. Asn-Trp dipeptides improve the oxidative stress and learning dysfunctions in D-galactose-induced BALB/c mice. Food Funct. 2014 Sep;5(9):2228-36.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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