ASP1126
ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.
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- CAS. Nr.: 1228580-11-7
- Formel: C26H26ClF6NO5
- Molecular Weight:581.93
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
EC50: 7.12 nM (hS1P1), 517 nM (hS1P3)[1].
ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ACI and Lewis rats aged 6 weeks were used as cardiac donors and recipients, respectively[1].
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Dosage:0.2 mg/kg, 1 mg/kg, 5 mg/kg.
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Administration:Orally once daily for 14 days.
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Result:Significantly prolonged allograft survival (median survival time [MST] =9; 8 days at 1 and 5 mg/kg, respectively, compared with 6 days in the vehicle group).
Chemical Information
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CAS. Nr. 1228580-11-7
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Molecular Weight 581.93
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Formel C26H26ClF6NO5
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SMILES
O=C(C1CCN(CC2=CC3=CC=C(OCC4=CC=C(OCC(F)(F)F)C(C(F)(F)F)=C4)C=C3OC2)CC1)O.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ASP1126 Related Classifications
HY-125881 Related Classifications
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