Biotin-PFP ester
Based on 1 Customer Validation
Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
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- Reinheit: 97.0%
- CAS. Nr.: 120550-35-8
- Formel: C16H15F5N2O3S
- Molecular Weight:410.36
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 120550-35-8
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Appearance Solid
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Molecular Weight 410.36
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Formel C16H15F5N2O3S
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Color White to off-white
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SMILES
O=C1N[C@]2(CS[C@H]([C@]2(N1)[H])CCCCC(OC3=C(C(F)=C(C(F)=C3F)F)F)=O)[H]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (121.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4369 mL | 12.1844 mL | 24.3688 mL | 60.9221 mL |
| 5 mM | 0.4874 mL | 2.4369 mL | 4.8738 mL | 12.1844 mL | |
| 10 mM | 0.2437 mL | 1.2184 mL | 2.4369 mL | 6.0922 mL | |
| 15 mM | 0.1625 mL | 0.8123 mL | 1.6246 mL | 4.0615 mL | |
| 20 mM | 0.1218 mL | 0.6092 mL | 1.2184 mL | 3.0461 mL | |
| 25 mM | 0.0975 mL | 0.4874 mL | 0.9748 mL | 2.4369 mL | |
| 30 mM | 0.0812 mL | 0.4061 mL | 0.8123 mL | 2.0307 mL | |
| 40 mM | 0.0609 mL | 0.3046 mL | 0.6092 mL | 1.5231 mL | |
| 50 mM | 0.0487 mL | 0.2437 mL | 0.4874 mL | 1.2184 mL | |
| 60 mM | 0.0406 mL | 0.2031 mL | 0.4061 mL | 1.0154 mL | |
| 80 mM | 0.0305 mL | 0.1523 mL | 0.3046 mL | 0.7615 mL | |
| 100 mM | 0.0244 mL | 0.1218 mL | 0.2437 mL | 0.6092 mL |
Biotin-PFP ester Related Classifications
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