BMS-502
Based on 1 publication(s) in Google Scholar
BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research.
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- Reinheit: 99.31%
- CAS. Nr.: 2407854-18-4
- Formel: C27H22F2N6O3
- Molecular Weight:516.50
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BMS-502
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Biologische Aktivität
IC50: 4.6 nM (DGK α), 2.1nM (DGK ζ)[1].
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Cell Line
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Type | Value | Description | References |
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| Raji | IC50 |
0.037 μM
Compound: 22; BMS-502
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Cytotoxicity against PD-1 negative human Raji cells measured after 24 hrs by Cell titer glo assay
Cytotoxicity against PD-1 negative human Raji cells measured after 24 hrs by Cell titer glo assay
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[PMID: 37465293] |
| Raji | IC50 |
0.037 μM
Compound: 22; BMS-502
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Cytotoxicity against PD-1 positive human Raji cells measured after 24 hrs by Cell titer glo assay
Cytotoxicity against PD-1 positive human Raji cells measured after 24 hrs by Cell titer glo assay
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[PMID: 37465293] |
Pharmacokinetic Analysis in C57 black mice Model[1]
| Route | Dose (mg/kg) | AUClast (μM•h) | t1/2 (h) | Tmax (h) | Cmax (μM) | Cl (m/min/kg) | Vss (mL/kg) | F (%) |
| i.v. | 1 | 14.8 | 22.5 | / | / | 1.9 | 3.9 | / |
| p.o. | 5 | 48 | / | 3.0 | 1.08 | / | / | 65 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OT-1 mouse model[1]
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Dosage:0-10 mg/kg
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Administration:Oral administration; 24 h
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Result:Caused no significant increase in activated effector T-cells.
Chemical Information
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CAS. Nr. 2407854-18-4
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Appearance Solid
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Molecular Weight 516.50
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Formel C27H22F2N6O3
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Color Light yellow to yellow
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SMILES
N#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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bioRxiv
In Cellulo pharmacological profiling and genomic editing reveals paralog-specific targets for PA generation during PLC signaling. [Abstract]2026 Mar 12:2026.03.02.709100. PMID: 41867796
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (193.61 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9361 mL | 9.6805 mL | 19.3611 mL | 48.4027 mL |
| 5 mM | 0.3872 mL | 1.9361 mL | 3.8722 mL | 9.6805 mL | |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9361 mL | 4.8403 mL | |
| 15 mM | 0.1291 mL | 0.6454 mL | 1.2907 mL | 3.2268 mL | |
| 20 mM | 0.0968 mL | 0.4840 mL | 0.9681 mL | 2.4201 mL | |
| 25 mM | 0.0774 mL | 0.3872 mL | 0.7744 mL | 1.9361 mL | |
| 30 mM | 0.0645 mL | 0.3227 mL | 0.6454 mL | 1.6134 mL | |
| 40 mM | 0.0484 mL | 0.2420 mL | 0.4840 mL | 1.2101 mL | |
| 50 mM | 0.0387 mL | 0.1936 mL | 0.3872 mL | 0.9681 mL | |
| 60 mM | 0.0323 mL | 0.1613 mL | 0.3227 mL | 0.8067 mL | |
| 80 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6050 mL | |
| 100 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4840 mL |
BMS-502 Related Classifications
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