Art. -Nr.: HY-160141

Catadegbrutinib

(Synonyms: BGB-16673; BTK-IN-29)

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Based on 1 Customer Validation

BGB-16673 (BGB-16673) is an orally active, selective BTK PROTAC degrader (IC₅₀=0.69 nM). BGB-16673 ligates BTK to E3 ubiquitin ligase, causing BTK to undergo polyubiquitination, which is then recognized and degraded by the proteasome, thereby exerting efficient BTK degradation activity. BGB-16673 can be used in the research of B-cell malignancies such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma.
(Pink: Btk ligand (HY-175788); Blue: Cereblon ligand (HY-W245311); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.18%
CAS. Nr.: 2736508-60-2
Formel: C₄₇H₅₄N₁₂O₄
Molecular Weight:851.01

Speicherung:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Catadegbrutinib Chemical Structure

CAS. Nr.: 2736508-60-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BGB-16673 (BGB-16673) is an orally active, selective BTK PROTAC degrader (IC₅₀=0.69 nM). BGB-16673 ligates BTK to E3 ubiquitin ligase, causing BTK to undergo polyubiquitination, which is then recognized and degraded by the proteasome, thereby exerting efficient BTK degradation activity. BGB-16673 can be used in the research of B-cell malignancies such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma^[1]^[2]^[3]. (Pink: Btk ligand (HY-175788); Blue: Cereblon ligand (HY-W245311); Black: linker).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle NF-κB Isoform-spezifische Produkte anzeigen :

In Vivo

Catadegbrutinib (6-20 mg/kg; p.o.) inhibits tumor growth in the REC‑1 lymphoma mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NCG mice treated REC-1 cancer cells^[2]
Dosage:

6 mg/kg; 20 mg/kg
Administration:

p.o.
Result:

Exhibited dose-dependent tumor growth inhibition.
Caused greater inhibition of cell-cycle-related genes than BTK inhibitors and more effectively inhibited NFκB targets than BTK inhibitors.

Chemical Information

CAS. Nr. 2736508-60-2
Appearance Solid
Molecular Weight 851.01
Formel C₄₇H₅₄N₁₂O₄
Color Light yellow to green yellow
SMILES

CC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)C=C5)=C4)=NC=N3)=C1
Synonyms

BGB-16673; BTK-IN-29
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (146.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1751 mL

5.8754 mL

11.7507 mL

5 mM

0.2350 mL

1.1751 mL

2.3501 mL

10 mM

0.1175 mL

0.5875 mL

1.1751 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang H, et al. BGB-16673, a selective BTK degrader, exhibits deeper inhibition of cancer cell signaling pathways and better efficacy in MCL models. Blood, 2024, 144: 5833.

[2]. Wu Y, et al. Translational modelling to predict human pharmacokinetics and pharmacodynamics of a Bruton's tyrosine kinase-targeted protein degrader BGB-16673. Br J Pharmacol. 2024 Dec;181(24):4973-4987. [Content Brief]

[3]. Hexiang Wang, et al. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use. WO2021219070A1. 2021-11-04.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1751 mL	5.8754 mL	11.7507 mL	29.3769 mL
	5 mM	0.2350 mL	1.1751 mL	2.3501 mL	5.8754 mL
	10 mM	0.1175 mL	0.5875 mL	1.1751 mL	2.9377 mL
	15 mM	0.0783 mL	0.3917 mL	0.7834 mL	1.9585 mL
	20 mM	0.0588 mL	0.2938 mL	0.5875 mL	1.4688 mL
	25 mM	0.0470 mL	0.2350 mL	0.4700 mL	1.1751 mL
	30 mM	0.0392 mL	0.1958 mL	0.3917 mL	0.9792 mL
	40 mM	0.0294 mL	0.1469 mL	0.2938 mL	0.7344 mL
	50 mM	0.0235 mL	0.1175 mL	0.2350 mL	0.5875 mL
	60 mM	0.0196 mL	0.0979 mL	0.1958 mL	0.4896 mL
	80 mM	0.0147 mL	0.0734 mL	0.1469 mL	0.3672 mL
	100 mM	0.0118 mL	0.0588 mL	0.1175 mL	0.2938 mL

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Catadegbrutinib

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Lactylation Compound Library

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Protein Tyrosine Kinase Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle NF-κB Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Catadegbrutinib Related Classifications

HY-160141 Related Classifications